2. Anti-infection
  3. Dengue virus Virus Protease
  4. DV-B-120

DV-B-120 是登革热病毒 (DENV) 的竞争性抑制剂，通过抑制 NS2B-NS3 蛋白酶，抑制 DENV-1，DENV-2，DENV-3 和 DENV-4，IC50 分别为 5.35，7.39，10.49 和 8.58 μM。DV-B-120 通过抑制 DENV 复制来发挥抗病毒活性。

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DV-B-120 Chemical Structure

DV-B-120 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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Customer Review

DV-B-120 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DV-B-120 is a competitive inhibitor for dengue virus (DENV) with IC50s of 5.35, 7.39, 10.49 and 8.58 μM, for DENV-1, DENV-2, DENV-3 and DENV-4, respectively, by inhibiting NS2B-NS3 protease. DV-B-120 exhibits antiviral activity through inhibition of DENV replication[1].

IC50 & Target

IC50: 5.35 μM (DENV-1), 7.39 μM (DENV-2), 10.49 μM (DENV-3), 8.58 μM (DENV-4)
体内研究
(In Vivo)

DV-B-120 (1-10 mg/kg，b.i.d，脑室内注射，5 天) 通过激活干扰素 (IFN) 和抗病毒的 IFN 刺激基因 (ISG)，抑制感染 DENV-2 的 ICR 乳鼠的死亡，以及相关疾病症状[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DENV-2 infected ICR suckling mice[1]
Dosage: 1-10 mg/kg
Administration: every other day, for 3 injection, intracerebral injection
Result: Inproved the survival rate, prevented the life-threatening symptoms.
分子量

466.53

Formula

C23H18N2O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DV-B-120 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DV-B-120Dengue virusVirus ProteaseDENVICR mouseHuh-7competitiveInhibitorinhibitorinhibit

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产品名称：
DV-B-120
目录号：
HY-162485
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