2. Metabolic Enzyme/Protease
  3. TrxR
  4. DVD-445

DVD-445 (Compound 7) 是一种有效的拟肽共价硫氧还蛋白还原酶1 (TrxR1) 抑制剂，IC50 为 0.60 μM。DVD-445 具有良好的抗癌应用。

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DVD-445 Chemical Structure

DVD-445 Chemical Structure

CAS No. : 2375846-41-4

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1584
In-stock
1 mg ￥654
In-stock
5 mg ￥1440
In-stock
10 mg ￥2250
In-stock
25 mg ￥4950
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

DVD-445 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DVD-445 (Compound 7) is a potent peptidomimetic covalent thioredoxin reductase 1 (TrxR1) inhibitor with an IC50 of 0.60 μM for rat TrxR1. DVD-445 has good anticancer application[1].

IC50 & Target

IC50: 0.60 μM (rat TrxR1)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HaCaT IC50
8.3 μM
Compound: 7; DVD-445
Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HaCaT assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31400708]
MRC5 IC50
11.85 μM
Compound: DVD-445
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32087464]
PBMC IC50
55.71 μM
Compound: 7; DVD-445
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human PBMC assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31400708]
SH-SY5Y IC50
10.99 μM
Compound: 7; DVD-445
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31400708]
SH-SY5Y IC50
7.26 μM
Compound: 7; DVD-445
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
Inhibition of TrxR in human SH-SY5Y cells using DTNB as substrate preincubated for 15 mins followed by substrate addition and measured for 20 mins by Ellman's method
[PMID: 31400708]
U-87MG ATCC IC50
8.9 μM
Compound: DVD-445
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 32087464]
U-87MG ATCC IC50
9.7 μM
Compound: 7; DVD-445
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31400708]
体外研究
(In Vitro)

DVD-445 (Compound 7) shows a cytotoxic effect in SH-SY5Y, U87, HaCaT cell lines and PBMCs with IC50s of 10.99 μM, 9.70 μM, 8.30 μM, 55.71 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DVD-445 相关抗体:
分子量

458.50

Formula

C25H28F2N2O4
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (218.10 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1810 mL 10.9051 mL 21.8103 mL
5 mM 0.4362 mL 2.1810 mL 4.3621 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DVD-445 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1810 mL 10.9051 mL 21.8103 mL 54.5256 mL
5 mM 0.4362 mL 2.1810 mL 4.3621 mL 10.9051 mL
10 mM 0.2181 mL 1.0905 mL 2.1810 mL 5.4526 mL
15 mM 0.1454 mL 0.7270 mL 1.4540 mL 3.6350 mL
20 mM 0.1091 mL 0.5453 mL 1.0905 mL 2.7263 mL
25 mM 0.0872 mL 0.4362 mL 0.8724 mL 2.1810 mL
30 mM 0.0727 mL 0.3635 mL 0.7270 mL 1.8175 mL
40 mM 0.0545 mL 0.2726 mL 0.5453 mL 1.3631 mL
50 mM 0.0436 mL 0.2181 mL 0.4362 mL 1.0905 mL
60 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.9088 mL
80 mM 0.0273 mL 0.1363 mL 0.2726 mL 0.6816 mL
100 mM 0.0218 mL 0.1091 mL 0.2181 mL 0.5453 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DVD-4452375846-41-4DVD445DVD 445TrxRThioredoxin ReductaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-126322
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