2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Caspase PARP Apoptosis MDM-2/p53
  4. Epifriedelanol

Epifriedelanol  (Synonyms: 表木栓醇)

目录号: HY-N1931 纯度: ≥98.0%
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Epifriedelanol 是从 Ulmus davidiana 根皮中分离的一种三萜类化合物。Epifriedelanol 诱导 DU145 细胞凋亡 (apoptosis)。Epfriedelanol 具有抗肿瘤和抗炎作用。Epifriedelanol 能抑制人原始细胞衰老。

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Epifriedelanol Chemical Structure

Epifriedelanol Chemical Structure

CAS No. : 16844-71-6

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Epifriedelanol 相关抗体

Top Publications Citing Use of Products

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Epifriedelanol is a triterpenoid isolated from the root bark of Ulmus davidiana. Epifriedelanol induces apoptosis in DU145 cells. Epifriedelanol has antitumor and anti-inflammatory activities. Epifriedelanol inhibits cellular senescence in human primary cells[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MCF7 GI50
> 100 μM
Compound: 9
Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
[PMID: 11678649]
NCI-H460 GI50
> 100 μM
Compound: 9
Cytotoxicity against human NCI-H460 cells by SRB assay
Cytotoxicity against human NCI-H460 cells by SRB assay
[PMID: 11678649]
SF-268 GI50
> 100 μM
Compound: 9
Cytotoxicity against human SF268 cells by SRB assay
Cytotoxicity against human SF268 cells by SRB assay
[PMID: 11678649]
TK-10 GI50
> 100 μM
Compound: 9
Cytotoxicity against human TK10 cells by SRB assay
Cytotoxicity against human TK10 cells by SRB assay
[PMID: 11678649]
UACC-62 GI50
> 100 μM
Compound: 9
Cytotoxicity against human UACC62 cells by SRB assay
Cytotoxicity against human UACC62 cells by SRB assay
[PMID: 11678649]
体外研究
(In Vitro)

Epifriedelanol (40-60 μg/disc) 在马铃薯盘生物测定研究中表现出显著的体外抗肿瘤特性[1]。
Epifriedelanol (10-50 μg/mL，3 天) 可在 HDF 和 HUVEC 细胞中抑制 Doxorubicin (HY-15142A) (adriamycin) 诱导的细胞衰老以及复制性衰老[2]。
Epifriedelanol (10-100μg/mL，5 小时) 以剂量依赖性方式抑制 adriamycin 引起的 p53 和 p21 蛋白水平升高[2]。
Epifriedelanol (0-50 μM，24-72 小时) 处理 DU145 和 PC3 细胞 72 小时时，其 IC50s 分别为 32.32， 35.22 μM[3]。
Epifriedelanol (5-10μM，48 小时) 诱导 DU145 细胞凋亡[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Epifriedelanol 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 10, 30, 50 μg/mL
Incubation Time: 3 days
Result: Inhibited senescence associated β-galactosidase (SA-β-gal) activity.
Had some cytotoxic effect in HUVECs but not in HDFs upon treatment with 50 µg/mL.
Decreased intracellular ROS levels augmented by adriamycin treatment.
Might be able to inhibit replicative senescence.

Western Blot Analysis[2]

Cell Line: Human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs)
Concentration: 10, 30, 50, 100 μg/mL
Incubation Time: 5 h (1 h prior to 500 nM adriamycin treatment, then incubation for 4 h)
Result: Repressed the levels of p53 and p21 proteins increased by adriamycin treatment in a dose-dependent manner.

Western Blot Analysis[3]

Cell Line: DU145 (human prostate cancer cell line)
Concentration: 5, 10μM
Incubation Time: 48 h
Result: Showed enhanced caspase 3 cleavage and downstream PARP, upregulation of pro-apoptotic P53 and BAX while down-regulation of anti-apoptotic NF-κB and BCL2.
体内研究
(In Vivo)

Epifriedelanol (5-10 mg/kg, 持续 21 天) 能降低 Bisphenol A (BPA) (HY-18260) 诱导的性腺毒性，且具有抗炎作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, (180-200 g, age of 9-10 weeks)[3]
Dosage: 5, 10 mg/kg
Administration: 21 days
Result: Showed a substantial decrease in prostate weight treated with Bisphenol A (BPA) (HY-18260), which could increase prostate size.
Did not exhibit any detectable alterations in hematologic parameters when compared to the control group, supporting its biosafety and application in in vivo systems.
Was preemptive against BPA-induced toxicity at both its high (10 mg/kg) and low (5 mg/kg) doses.
Effectively retained physiological serum estradiol concentrations in a dose-dependent manner.
Reduced peroxidation, and suppression of inflammatory markers (NO, IL-6 and TNF-α), indicating substantial antiinflammatory potential.
分子量

428.73

Formula

C30H52O
CAS 号
性状

固体

颜色

White to off-white

中文名称

表木栓醇
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

THF 中的溶解度 : 10 mg/mL (23.32 mM; 超声助溶)

Acetone 中的溶解度 : < 1 mg/mL (insoluble)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble)

Ethanol 中的溶解度 : < 1 mg/mL (insoluble)

DMF 中的溶解度 : < 1 mg/mL (insoluble)

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3325 mL 11.6624 mL 23.3247 mL
5 mM 0.4665 mL 2.3325 mL 4.6649 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Epifriedelanol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
THF 1 mM 2.3325 mL 11.6624 mL 23.3247 mL 58.3118 mL
5 mM 0.4665 mL 2.3325 mL 4.6649 mL 11.6624 mL
10 mM 0.2332 mL 1.1662 mL 2.3325 mL 5.8312 mL
15 mM 0.1555 mL 0.7775 mL 1.5550 mL 3.8875 mL
20 mM 0.1166 mL 0.5831 mL 1.1662 mL 2.9156 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epifriedelanol16844-71-6表木栓醇CaspasePARPApoptosisMDM-2/p53poly ADP ribose polymerase HDFanti-tumoranti-inflammationHUVECsenescenceDU145Inhibitorinhibitorinhibit

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