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  4. EPZ033294

EPZ033294 是 SYMD2 的抑制剂 (IC50为 3.9 nM)。SYMD2 本身具有催化活性，可以将 BTF3 的赖氨酸残基甲基化为 BTF3me1，实验通过检测 SYMD2 抑制 BTF3me1 的 IC50 为 2.9 nM，说明 EPZ033294 对 SYMD2 的活性抑制。EPZ033294 (0-50 µM) 在 293T 细胞中抑制 SYMD2 且有浓度依赖性的抑制作用[1][2]。

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EPZ033294 Chemical Structure

EPZ033294 Chemical Structure

CAS No. : 1887195-17-6

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EPZ033294 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EPZ033294 is an inhibitor of SYMD2 (IC50 is 3.9 nM). SYMD2 itself has catalytic activity and can methylate the lysine residue of BTF3 to BTF3me1, which was experimentally demonstrated by detecting an IC50 of 2.9 nM for inhibition of BTF3ME1 by SYMD2, indicating an active inhibition of SYMD2 by EPZ033294. EPZ033294 (0-50 µM) has an inhibitory effect on SYMD2 and a concentration-dependent inhibitory effect in 293T[1].

IC50 & Target

SYMD2 [1]
体外研究
(In Vitro)

EPZ033294 (0-50 µM) 在 293T 细胞中抑制 SMYD2 且有浓度依赖性的抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

EPZ033294 相关抗体:

Western Blot Analysis[1]

Cell Line: 293T
Concentration: 0, 3.12, 6.25, 12.5, 25 and 50 µM
Incubation Time: 1000 s
Result: Inhibited SMYD2.
分子量

411.89

Formula

C20H22ClN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EPZ033294 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EPZ0332941887195-17-6EPZ 033294EPZ-033294OthersNon-competitive ligandSMYD2 inhibitorMethylation inhibitorInhibitorinhibitorinhibit

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产品名称：
EPZ033294
目录号：
HY-164144
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