2. NF-κB PI3K/Akt/mTOR Immunology/Inflammation Metabolic Enzyme/Protease
  3. NF-κB Akt Nuclear Factor of activated T Cells (NFAT) Phosphatase
  4. Eudebeiolide B

Eudebeiolide B  (Synonyms: Plebeiolide D)

目录号: HY-N11775
产品使用指南

摩尔计算器

Eudebeiolide B 是一种可以从荔枝草中分离出来的化合物。Eudebeiolide B 通过调节 RANKL 诱导的 NF-κB、c-Fos 和钙信号，抑制破骨细胞生成，可用于破骨细胞相关疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Eudebeiolide B Chemical Structure

Eudebeiolide B Chemical Structure

CAS No. : 1934299-51-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Eudebeiolide B 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research[1].

IC50 & Target[1]

Akt

 

NF-κB

 

体外研究
(In Vitro)

Eudebeiolide B (1-30 μΜ，1 小时) 在小鼠骨髓巨噬细胞中抑制 RANKL 诱导的细胞分化，抑制破骨细胞生成相关标志基因的表达和 RANKL 介导的细胞信号传导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Eudebeiolide B 相关抗体:

Cell Differentiation Assay[1]

Cell Line: Bone marrow macrophages (BMMs)
Concentration: 1-30 μΜ
Incubation Time: 1 hours
Result: Inhibited RANKL-induced osteoclast differentiation of BMMs, bone resorption, and promotes osteoblast differentiation.

RT-PCR[1]

Cell Line: Bone marrow macrophages (BMMs), MC3T3-E1 cells
Concentration: 10 μΜ
Incubation Time: 1 hours
Result: Downregulated the expression of NFATc1 and c-fos, transcription factors induced by RANKL.
Attenuated the RANKL-induced expression of osteoclastogenesis-related genes, including Ctsk, MMP9 and DC-STAMP.
Induced the expression of alkaline phosphatase (ALP) and calcium accumulation during MC3T3-E1 osteoblast differentiation.

Western Blot Analysis[1]

Cell Line: Bone marrow macrophages (BMMs)
Concentration: 10 μΜ
Incubation Time: 1 hours
Result: Inhibited the phosphorylation of Akt and NF-κB p65.
Downregulated the expression of CREB, Btk and phospholipase PLCγ2 in RANKL-induced calcium signaling.
体内研究
(In Vivo)

Eudebeiolide B (5 或 10 mg/kg 灌胃.，每天 1 次，持续 6 周) 在卵巢切除（OVX）小鼠模型中，可预防双侧卵巢切除 (OVX) 引起的骨质流失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized (OVX) mouse model[1]
Dosage: 5 or 10 mg/kg
Administration: After 6 weeks of ovarian resection, intragastric injection (i.g.) once daily for 6 weeks.
Result: Prevented bone mineral density (BMD) loss and bone mineral content (BMC) loss compared to the OVX mice.
分子量

262.30

Formula

C15H18O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Eudebeiolide B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eudebeiolide B1934299-51-0Plebeiolide DNF-κBAktNuclear Factor of activated T Cells (NFAT)PhosphataseNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BMC3T3-E1Bone marrow macrophagesBMMsOsteoclastogenesis InhibitorSalvia plebeiaInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Eudebeiolide B
目录号：
HY-N11775
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z