2. Autophagy
  3. Autophagy
  4. Euxanthone

Euxanthone 是一种氧杂蒽酮衍生物，可通过触发自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 具有抗肿瘤和神经保护活性。

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Euxanthone Chemical Structure

Euxanthone Chemical Structure

CAS No. : 529-61-3

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1 mg ￥2380
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Euxanthone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 200 μM
Compound: 8
Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human A549 cells measured after 48 hrs by MTT assay
[PMID: 28065566]
A549 IC50
14.5 mg/mL
Compound: 13
Cytotoxicity against human A549 cells after 3 days by SRB assay
Cytotoxicity against human A549 cells after 3 days by SRB assay
[PMID: 15568778]
HeLa S3 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HeLaS3 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
HepG2 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HepG2 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
HT-29 IC50
> 10 μM
Compound: 19
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human HT-29 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
KB IC50
> 10 μM
Compound: 19
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
Cytotoxicity in human KB cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
MCF7 IC50
> 10 μM
Compound: 19
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
Cytotoxicity in human MCF7 cells incubated for 72 hrs by MTT assay
[PMID: 30978023]
MCF7 IC50
19.5 mg/mL
Compound: 13
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
Cytotoxicity against human MCF7 cells after 3 days by SRB assay
[PMID: 15568778]
NCI/ADR-RES IC50
> 200 μM
Compound: 8
Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
Cytotoxicity against human MCF7/ADR cells measured after 48 hrs by MTT assay
[PMID: 28065566]
OVCAR-3 IC50
> 10 μM
Compound: 27
Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human OVCAR3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 30830783]
SK-OV-3 IC50
> 10 μM
Compound: 27
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
Antiproliferative activity against human SKOV3 cells assessed as reduction in cell viability after 48 hrs by CCK8 assay
[PMID: 30830783]
SMMC-7721 IC50
60.35 μM
Compound: 8
Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
Cytotoxicity against Taxol-resistant human SMMC7721 cells measured after 48 hrs by MTT assay
[PMID: 28065566]
体外研究
(In Vitro)

Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力，并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]。
Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Euxanthone 相关抗体:

Cell Migration Assay [1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Inhibited cell migration at 24 hr.

Western Blot Analysis[1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
体内研究
(In Vivo)

在肺转移模型中，Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]。
Euxanthone（30-60 mg/kg；口服；每天一次；持续 7 天）处理使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2]
Dosage: 30 mg/kg, 60 mg/kg
Administration: p.o.;once a day; for 7 days
Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
分子量

228.20

Formula

C13H8O4
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

优咕吨酮
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料
参考文献

Euxanthone 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Euxanthone529-61-3优咕吨酮Autophagyoxidative stressxanthoneanti-neoplastic and neuroprotective activitiesCOX-2anti-metastaticInhibitorinhibitorinhibit

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