2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Farnesyl thiosalicylic acid amide

Farnesyl thiosalicylic acid amide  (Synonyms: FTS amide; Salirasib amide)

目录号: HY-112666
产品使用指南 技术支持

Farnesyl thiosalicylic acid amide (FTS-A) 是一种具有口服活性的 farnesyl thiosalicylic acid (HY-14754) 的衍生物。Farnesyl thiosalicylic Acid amide 可降低 Ras-GTP 水平并抑制细胞生长，对于 Panc-1 和 U87 细胞 IC50 分别为 20 和 10 μM。Farnesyl thiosalicylic acid amide 可用于癌症的研究。

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Farnesyl thiosalicylic acid amide Chemical Structure

Farnesyl thiosalicylic acid amide Chemical Structure

CAS No. : 1092521-74-8

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规格 价格 是否有货 数量
1 mg ￥760
3 - 4 周
5 mg ￥2320
3 - 4 周
10 mg   询价  
50 mg   询价  

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Farnesyl thiosalicylic acid amide 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Farnesyl thiosalicylic acid amide (FTS-A) is an orally active derivative of farnesyl thiosalicylic acid (HY-14754). Farnesyl thiosalicylic acid amide reduces Ras-GTP levels and inhibits cell growth with IC50s of 20 and 10 μM for Panc-1 and U87 cells, respectively. Farnesyl thiosalicylic acid amide can be used for the research of cancer[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BXPC-3 EC50
> 20 μM
Compound: FTSA
Cytotoxicity against human BxPC3 cells after 48 hrs by fluorescence assay
Cytotoxicity against human BxPC3 cells after 48 hrs by fluorescence assay
[PMID: 24852279]
MIA PaCa-2 EC50
> 20 μM
Compound: FTSA
Cytotoxicity against human MIAPaCa2 cells harboring K-Ras mutant oncogene after 48 hrs by fluorescence assay
Cytotoxicity against human MIAPaCa2 cells harboring K-Ras mutant oncogene after 48 hrs by fluorescence assay
[PMID: 24852279]
PANC-1 IC50
20 μM
Compound: FTS-A
Cytotoxicity against human PANC1 cells after 5 to 7 days
Cytotoxicity against human PANC1 cells after 5 to 7 days
[PMID: 19072665]
U-87MG ATCC IC50
10 μM
Compound: FTS-A
Cytotoxicity against human U87 cells after 5 to 7 days
Cytotoxicity against human U87 cells after 5 to 7 days
[PMID: 19072665]
体外研究
(In Vitro)

Farnesyl thiosalicylic acid amide (50 μM, 24 h) 降低 Panc-1 和 U87 细胞中总 Ras-GTP 和 K-Ras-GTP 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Farnesyl thiosalicylic acid amide 相关抗体:

Western Blot Analysis[1]

Cell Line: U87 cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Reduced the level of N-Ras-GTP, phospho-ERK and phospho-AKT.
体内研究
(In Vivo)

Farnesyl thiosalicylic acid amide (100 mg/kg, 灌胃, 一次) 抑制 Panc-1 裸鼠模型中肿瘤生长[1]。
Farnesyl thiosalicylic acid amide (100 mg/kg, 口服, 一天两次, 14 天) 抑制 U87 裸鼠模型中肿瘤生长[1]。

药代动力学分析[1]

Route Dose (mg/kg) half-life (min) Tmax (h) Cmax (ng/mL) AUC0-inf (min*ng/mL)
i.g. 100 314 110 371 108783

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

357.55

Formula

C22H31NOS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Farnesyl thiosalicylic acid amide 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farnesyl thiosalicylic acid amide1092521-74-8FTS amide Salirasib amideRasPanc-1U87cancerRas-GTPorally activeInhibitorinhibitorinhibit

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