2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Fluoroethylnormemantine hydrochloride

Fluoroethylnormemantine hydrochloride 

目录号: HY-139048A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Fluoroethylnormemantine hydrochloride 是 Memantine 的衍生物，是 N-甲基-D-天冬氨酸 (NMDA) 受体的拮抗剂。[18F]-Fluoroethylnormemantine hydrochloride 可用作正电子发射断层扫描 (PET) 示踪剂。Fluoroethylnormemantine hydrochloride 具有抗遗忘、神经保护、抗抑郁样和减轻恐惧的作用。

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Fluoroethylnormemantine hydrochloride Chemical Structure

Fluoroethylnormemantine hydrochloride Chemical Structure

CAS No. : 1639210-25-5

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规格 价格 是否有货 数量
1 mg ￥280
In-stock
5 mg ￥700
In-stock
10 mg ￥1120
In-stock
25 mg ￥2250
In-stock
50 mg ￥3600
In-stock
100 mg ￥5400
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Fluoroethylnormemantine hydrochloride:

Fluoroethylnormemantine hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fluoroethylnormemantine hydrochloride, a derivative of Memantine, is an antagonist of the N-methyl-D-aspartate (NMDA) receptor. [18F]-Fluoroethylnormemantine hydrochloride can be used as a positron emission tomography (PET) tracer. Fluoroethylnormemantine hydrochloride exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects[1][2][3].

IC50 & Target

NMDA receptor[1]
体内研究
(In Vivo)

Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ 25-35-induced learning impairments in mice[1].
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ 25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1]
Dosage: 0.1, 0.3, 1, 3, 10 mg/kg
Administration: I.p. 30 minutes before the behavioral tests
Result: Attenuated Aβ 25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit.
Clinical Trial
分子量

233.75

Formula

C12H21ClFN
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (427.81 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.2781 mL 21.3904 mL 42.7808 mL
5 mM 0.8556 mL 4.2781 mL 8.5561 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (268 KB) HNMR (118 KB)

产品使用指南 (1538 KB)
参考文献

Fluoroethylnormemantine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2781 mL 21.3904 mL 42.7807 mL 106.9519 mL
5 mM 0.8556 mL 4.2781 mL 8.5561 mL 21.3904 mL
10 mM 0.4278 mL 2.1390 mL 4.2781 mL 10.6952 mL
15 mM 0.2852 mL 1.4260 mL 2.8520 mL 7.1301 mL
20 mM 0.2139 mL 1.0695 mL 2.1390 mL 5.3476 mL
25 mM 0.1711 mL 0.8556 mL 1.7112 mL 4.2781 mL
30 mM 0.1426 mL 0.7130 mL 1.4260 mL 3.5651 mL
40 mM 0.1070 mL 0.5348 mL 1.0695 mL 2.6738 mL
50 mM 0.0856 mL 0.4278 mL 0.8556 mL 2.1390 mL
60 mM 0.0713 mL 0.3565 mL 0.7130 mL 1.7825 mL
80 mM 0.0535 mL 0.2674 mL 0.5348 mL 1.3369 mL
100 mM 0.0428 mL 0.2139 mL 0.4278 mL 1.0695 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluoroethylnormemantine1639210-25-5iGluRIonotropic glutamate receptorsMemantineNMDApositronemissiontomographyPETtracerantidepressantfearanti-amnesicneuroprotectiveAlzheimerInhibitorinhibitorinhibit

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目录号：
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