2. Neuronal Signaling GPCR/G Protein Membrane Transporter/Ion Channel Anti-infection
  3. Dopamine Receptor Sodium Channel SARS-CoV
  4. Fluphenazine hydrochloride

Fluphenazine hydrochloride 是一种有效且具有口服活性的吩噻嗪类多巴胺受体 (dopamine receptor) 拮抗剂。Fluphenazine hydrochloride 阻断神经元电压门控的钠离子通道 (sodium channels)。Fluphenazine hydrochloride 主要通过拮抗中边缘、黑质纹状体和下颌结节神经通路的突触后多巴胺-2 受体来发挥作用。Fluphenazine hydrochloride 可拮抗苯甲酸甲酯诱导的小鼠刻板咬伤，抑制小鼠攀爬行为。Fluphenazine hydrochloride 可用于研究精神病以及与糖尿病相关的疼痛性周围神经病变，并有抑制 SARS-CoV-2 的潜力。

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Fluphenazine hydrochloride Chemical Structure

Fluphenazine hydrochloride Chemical Structure

CAS No. : 1254-47-3

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Fluphenazine hydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].

IC50 & Target

Dopamine receptor, Sodium channels, SARS-CoV-2[1][2]
体内研究
(In Vivo)

Fluphenazine (1 mg/kg；IG，从妊娠第 6 天到第 15 天进行) hydrochloride 会导致怀孕小鼠畸形[5]。
Fluphenazine (0.125-1 mg/kg；IP，单剂量) hydrochloride 拮抗 Methylphenidate 引起的刻板啃咬，显着抑制攀爬行为[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mature female Swiss-Webster mice[5]
Dosage: 1 mg/kg
Administration: IG, treated from day 6 to day 15 of gestation
Result: Significantly reduced fetal weight and length, increased the incidence of incomplete ossification of sternebrae and skull bones.
Animal Model: Mice (injected with 60 mg/kg Methylphenidate)[6]
Dosage: 0.125, 0.25, 0.5, and 1 mg/kg
Administration: IP, single dosage
Result: Antagonized Methylphenidate-induced stereotyped gnawing; inhibited significantly climbing behaviour in mice at 0.0625-0.5 mg/kg, and at the dose of 1 mg/kg abolished this effect completely.
分子量

473.98

Formula

C22H27ClF3N3OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fluphenazine hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluphenazine1254-47-3Dopamine ReceptorSodium ChannelSARS-CoVNa channelsNa+ channelsSARS coronavirusneuronal voltage-gated sodium channelsoralschizophreniaphenothiazinegnawingclimbing behaviourpsychosisdiabetesSARS-CoV-2malformationsSwiss-Webster miceInhibitorinhibitorinhibit

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