NAALAD2 - N-acetylated alpha-linked acidic dipeptidase 2 Gene

中文名称：N-乙酰化α-连接的酸性二肽酶 2

种属: Homo sapiens

同用名: GCP3; GCPIII; GPCIII

关于 NAALAD2

功能概要

该基因是 N-乙酰化 α 连接酸性二肽酶 (NAALADase) 基因家族的成员。该家族的代表成员是编码人前列腺特异性膜抗原 (PSM) 的基因，它是前列腺癌的标志物，也是第一个被证明具有 NAALADase 活性的基因。 NAALADase 裂解 N-乙酰基-L-天冬氨酸-L-谷氨酸 (NAAG) ，这是一种在中枢神经系统和周围神经系统中均有表达的神经肽，被认为具有神经递质的功能。该基因的产物是 II 型整合膜蛋白。该基因的瞬时转染赋予哺乳动物细胞 NAALADase 和二肽基肽酶 IV 活性。该基因在卵巢和睾丸以及离散的大脑区域中高度表达。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2014 年 7 月]

This gene is a member of the N-acetylated alpha-linked acidic dipeptidase (NAALADase) gene family. The representative member of this family is the gene encoding human prostate-specific membrane antigen (PSM), which is a marker of prostatic carcinomas and is the first to be shown to possess NAALADase activity. NAALADase cleaves N-acetyl-L-aspartate-L-glutamate (NAAG), which is a neuropeptide expressed both in the central nervous systems and in the periphery and is thought to function as a neurotransmitter. The product of this gene is a type II integral membrane protein. Transient transfection of this gene confers both NAALADase and dipetidyl peptidase IV activities to mammalian cells. This gene is highly expressed in ovary and testis as well as within discrete brain areas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]