1. Gene
  2. CD24 - CD24 molecule Gene

CD24 - CD24 molecule Gene

中文名称:CD24 分子

种属: Homo sapiens

同用名: CD24A

基因 ID: 100133941 | 基因类型: protein coding

关于 CD24

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:106,969,831-106,976,855 (from NCBI)

This gene has 8 transcripts (splice variants), 152 orthologues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 586.8), esophagus (RPKM 431.3) and 12 other tissues.

功能概要

该基因编码一种在成熟粒细胞和 B 细胞上表达的唾液酸糖蛋白,并调节这些细胞的生长和分化信号。前体蛋白被切割成一个短的 32 个氨基酸的成熟肽,该肽通过糖基磷脂酰肌醇 (GPI) 连接固定在细胞表面。该基因在之前的基因组组装中缺失,但位于 6 号染色体上。非转录的假基因已指定在 1 号、15 号、20 号和 Y 号染色体上。可变剪接导致多个转录变体。[RefSeq 提供,2014 年 4 月]

This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CD24 基因产物(5)

mRNA Protein Name
NM_001291737.1 NP_001278666.1 signal transducer CD24 isoform a preproprotein
NM_001291738.1 NP_001278667.1 signal transducer CD24 isoform a preproprotein
NM_001291739.1 NP_001278668.1 signal transducer CD24 isoform b
NM_001359084.1 NP_001346013.1 signal transducer CD24 isoform a preproprotein
NM_013230.3 NP_037362.1 signal transducer CD24 isoform a preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8753773 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
8753773 GOA
enables protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
11313396 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell receptor transport into membrane raft IDA
IDA: 通过直接分析推断
11313396 GOA
involved in T cell costimulation IDA
IDA: 通过直接分析推断
11272271 GOA
involved in cell activation IDA
IDA: 通过直接分析推断
8223854 GOA
involved in glomerular parietal epithelial cell differentiation IMP
IMP: 通过突变表型推断
19092120 GOA
involved in negative regulation of transforming growth factor beta3 production IMP
IMP: 通过突变表型推断
16930538 GOA
involved in podocyte differentiation IMP
IMP: 通过突变表型推断
19092120 GOA
involved in positive regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
12496407 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
11272271 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
2153173 GOA
involved in positive regulation of nephron tubule epithelial cell differentiation IMP
IMP: 通过突变表型推断
16885410 GOA
involved in regulation of MAPK cascade IDA
IDA: 通过直接分析推断
11313396 GOA
involved in regulation of phosphorylation IDA
IDA: 通过直接分析推断
11313396 GOA
involved in respiratory burst IDA
IDA: 通过直接分析推断
8223854 GOA
involved in response to estrogen IEP
IEP: 通过表达模式推断
10037815 GOA
involved in response to hypoxia IEP
IEP: 通过表达模式推断
15174142 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16532032 GOA
located in membrane IDA
IDA: 通过直接分析推断
10037815 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
11313396 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD24 蛋白结构

CD24

CD24: CD24 protein (26 - 79)

  • 0
  • 80 a.a.
蛋白主名 其他名称

signal transducer CD24

CD24 antigen (small cell lung carcinoma cluster 4 antigen)

重组 CD24 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70720 CD24 Protein, Human (S44T, HEK293, Fc) P25063-1 (S27-G59, S44T) ≥95%
HY-P70809 CD24 Protein, Human (HEK293, Fc) P25063-1 (S27-G59) ≥95%
HY-P72352 CD24 Protein, Human (Biotinylated, HEK293, Fc-Avi) P25063-1 (S27-G59) ≥95%
HY-P78088 CD24 Protein, Human (Biotinylated, HEK293, Fc) P25063-1 (S27-G59) ≥95%
HY-P78404 CD24 Protein, Human (HEK293, mFc) P25063-1 (S27-G59) ≥95%
HY-P78544 CD24 Protein-VLP, Human (HEK293) P25063-1 (S27-G59) ≥95%
HY-P78913 CD24 Protein, Human (Biotinylated, HEK293, His-Avi) P25063-1 (S27-G59) ≥95%
HY-P700401 CD24 Protein-Nanoparticle, Human (HEK293, His) P25063 (S27-G59) ≥95%

关联疾病

疾病名称 别名
Erythroleukemia
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord

Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Breast Carcinoma In Situ

Carcinoma In Situ Of Breast

Non-Infiltrating Carcinoma Of Breast

Breast Cancer In Situ

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

In Situ Carcinoma

Carcinoma In Situ

Colorectal Cancer, Hereditary Nonpolyposis, Type 8

HNPCC8

Hereditary Nonpolyposis Colorectal Cancer Type 8

Hereditary Non-Polyposis Colorectal Cancer 8

Cancer, Colorectal, Nonpolyposis, Hereditary, Type 8

Pre-Malignant Neoplasm
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Bronchiectasis 1
Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus CD24 VGNC VGNC:27014
Mus musculus CD24 MGD MGI:88323
Rattus norvegicus CD24 RGD RGD:2298
Canis familiaris CD24 NCBI NCBI:102155900
Macaca fascicularis CD24 NCBI NCBI:101867055