2. Gene
  3. IL18BP - interleukin 18 binding protein Gene

IL18BP - interleukin 18 binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 18 结合蛋白

种属: Homo sapiens

同用名: FVH; IL18BPa

基因 ID: 10068 | 基因类型: protein coding

关于 IL18BP

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,998,909-72,008,200 (from NCBI)

This gene has 18 transcripts (splice variants), 89 orthologues and is associated with 1 phenotype. Broad expression in spleen (RPKM 11.4), appendix (RPKM 6.6) and 24 other tissues.

功能概要

由该基因编码的蛋白质起着促炎细胞因子 IL18 抑制剂的作用。它结合 IL18，阻止 IL18 与其受体结合，从而抑制 IL18 诱导的 IFN-γ 产生，从而导致 1 型 T 辅助细胞免疫反应降低。该蛋白质在单核细胞中组成型表达和分泌。在克罗恩病患者的肠道组织中检测到这种蛋白质水平升高。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 2 月]

The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

IL18BP 基因产物(7)

mRNA Protein Name
NM_001039659.2 NP_001034748.1 interleukin-18-binding protein isoform a precursor
NM_001039660.2 NP_001034749.1 interleukin-18-binding protein isoform a precursor
NM_001145055.1 NP_001138527.1 interleukin-18-binding protein isoform b precursor
NM_001145057.1 NP_001138529.1 interleukin-18-binding protein isoform a precursor
NM_005699.3 NP_005690.2 interleukin-18-binding protein isoform c precursor
NM_173042.2 NP_766630.2 interleukin-18-binding protein isoform a precursor
NM_173044.3 NP_766632.2 interleukin-18-binding protein isoform d precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-18 binding IDA
IDA: 通过直接分析推断
10023777 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 1 type immune response IDA
IDA: 通过直接分析推断
10023777 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-18-binding protein

MC51L-53L-54L homolog gene product

重组 IL18BP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7211 IL-18BP Protein, Human (CHO) O95998-2 (T31-G194) ≥95%
HY-P72575 IL-18BP Protein, Human (HEK293, hFc) AAD17187.1 (T29-G192) ≥95%
HY-P77709 IL-18BP Protein, Human (HEK293, His) O95998-2 (T31-G194) ≥95%
HY-P78156 IL-18BP Protein, Human (Biotinylated, HEK293, His-Avi) O95998-2 (T31-G194) ≥95%

关联疾病

疾病名称 别名
Hepatitis, Fulminant Viral

Hepatitis, Fulminant Viral, Susceptibility To

FVH

Fulminant Viral Hepatitis

{Hepatitis, Fulminant Viral, Susceptibility To}
Molluscum Contagiosum

Water Warts

Molluscum Verrucosum
Cowpox

Yaba
Viral Hepatitis

Animal Viral Hepatitis

Hepatitis, Viral, Animal

Human Viral Hepatitis

Viral Hepatitis With Hepatic Coma
Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis
Adult-Onset Still'S Disease

Adult-Onset Still Disease

Adult Onset Still'S Disease

Adult Still'S Disease

Still'S Disease Adult Onset

Aosd

Wissler-Fanconi Syndrome

Stills Disease Adult-Onset

Still'S Disease, Adult-Onset

Wissler'S Syndrome
Smallpox

Variola

Ordinary Smallpox

Alastrim

Amaas
Toxic Optic Neuropathy
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Hemophagocytic Lymphohistiocytosis

Lymphohistiocytosis, Hemophagocytic

Haemophagocytic Syndrome

Lymphohistiocytosis Hemophagocytic

Hemophagocytic Syndrome

Familial Hemophagocytic Lymphocytosis

Histiocytoses Of Mononuclear Phagocytes

Haemophagocytic Lymphohistiocytosis Nos
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102019 NSC61610 Inhibitor 99.50% 否
HY-160793 NSC80734 Inhibitor 98.08% 否
HY-RS06709 IL18BP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IL18BP MGD MGI:1333800
Canis familiaris IL18BP VGNC VGNC:41952
Rattus norvegicus IL18BP RGD RGD:620042
Macaca mulatta IL18BP VGNC VGNC:73713
Bos taurus IL18BP VGNC VGNC:54438
Felis catus IL18BP VGNC VGNC:82043
Others IL18BP NCBI
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