1. Gene
  2. FEM1B - fem-1 homolog B Gene

FEM1B - fem-1 homolog B Gene

中文名称:fem-1 同系物 B

种属: Homo sapiens

同用名: F1AA; F1A-ALPHA; FEM1-beta

基因 ID: 10116 | 基因类型: protein coding

关于 FEM1B

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:68,277,745-68,295,862 (from NCBI)

This gene has 4 transcripts (splice variants), 113 orthologues and 4 paralogues. Ubiquitous expression in brain (RPKM 18.1), endometrium (RPKM 14.9) and 25 other tissues.

功能概要

该基因编码属于死亡受体相关蛋白家族的锚蛋白重复蛋白,并在介导细胞凋亡中发挥作用。编码的蛋白质也被认为通过与检查点激酶 1 的相互作用在复制应激诱导的检查点信号通路中发挥作用。[RefSeq 提供,2013 年 8 月]

This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating Apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

FEM1B 基因产物(1)

mRNA Protein Name
NM_015322.5 NP_056137.1 protein fem-1 homolog B

FEM1B 蛋白结构

Ank

Ank: Ankyrin repeat (48 - 68)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (92 - 183)

Ank

Ank: Ankyrin repeat (187 - 209)

Ank

Ank: Ankyrin repeat (218 - 241)

Ank

Ank: Ankyrin repeat (484 - 530)

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  • 627 a.a.
蛋白主名 其他名称

protein fem-1 homolog B

FEM-1-like death receptor binding protein

关联疾病

疾病名称 别名
Type C Thymoma

Thymoma, Type C

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FEM1B VGNC VGNC:72634
Canis familiaris FEM1B VGNC VGNC:40816
Bos taurus FEM1B VGNC VGNC:28945
Mus musculus FEM1B MGD MGI:1335087
Felis catus FEM1B VGNC VGNC:104392
Rattus norvegicus FEM1B RGD RGD:1304569