2. Gene
  3. PPM1F - protein phosphatase, Mg2+/Mn2+ dependent 1F Gene

PPM1F - protein phosphatase, Mg2+/Mn2+ dependent 1F Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶，Mg2+/Mn2+ 依赖性 1F

种属: Homo sapiens

同用名: CAMKP; FEM-2; POPX2; hFEM-2; CaMKPase

基因 ID: 9647 | 基因类型: protein coding

关于 PPM1F

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:21,919,425-21,952,848 (from NCBI)

This gene has 10 transcripts (splice variants), 206 orthologues and 16 paralogues. Ubiquitous expression in placenta (RPKM 16.9), spleen (RPKM 14.5) and 24 other tissues.

功能概要

该基因编码的蛋白质是 Ser/Thr 蛋白磷酸酶 PP2C 家族的成员。已知 PP2C 家族成员是细胞应激反应途径的负调节剂。这种磷酸酶可以与 Rho 鸟嘌呤核苷酸交换因子 (PIX) 相互作用，从而阻断 p21 激活激酶 1 (PAK) 的作用，PAK 是一种介导 Rho GTP 酶下游生物效应的蛋白激酶。发现钙/钙调蛋白依赖性蛋白激酶 II γ (CAMK2G/CAMK-II) 是该磷酸酶的底物之一。这种磷酸酶或 CAMK2G 的过表达已被证明可介导半胱天冬酶依赖性细胞凋亡。已识别出可变剪接的转录本变体，但尚未确定其全长性质。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This Phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-Activated Kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this Phosphatase. The overexpression of this Phosphatase or CAMK2G has been shown to mediate caspase-dependent Apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PPM1F 基因产物(2)

mRNA Protein Name
NM_001410836.1 NP_001397765.1 protein phosphatase 1F isoform 2
NM_014634.4 NP_055449.1 protein phosphatase 1F isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin-dependent protein phosphatase activity IDA
IDA: 通过直接分析推断
11559703 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11559703 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
11559703 GOA
enables protein serine/threonine phosphatase activity IMP
IMP: 通过突变表型推断
20016286 GOA
enables protein tyrosine/serine/threonine phosphatase activity IMP
IMP: 通过突变表型推断
24338362 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
20801214 GOA
involved in intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
11559703 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20016286 GOA
involved in negative regulation of cell-cell adhesion mediated by cadherin IMP
IMP: 通过突变表型推断
24338362 GOA
involved in negative regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
15140879 GOA
involved in negative regulation of protein kinase activity IDA
IDA: 通过直接分析推断
11864573 GOA
involved in negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
15140879 GOA
involved in negative regulation of protein transport IMP
IMP: 通过突变表型推断
24338362 GOA
involved in peptidyl-serine dephosphorylation IMP
IMP: 通过突变表型推断
24338362 GOA
involved in peptidyl-threonine dephosphorylation IDA
IDA: 通过直接分析推断
11559703 GOA
involved in positive regulation of cell migration IGI
IGI: 通过遗传相互作用推断
26498692 GOA
involved in positive regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of chemotaxis IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
11559703 GOA
involved in positive regulation of epithelial cell migration IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of growth IMP
IMP: 通过突变表型推断
20016286 GOA
involved in positive regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
11864573 GOA
involved in positive regulation of stress fiber assembly IGI
IGI: 通过遗传相互作用推断
26498692 GOA
involved in positive regulation of stress fiber assembly IMP
IMP: 通过突变表型推断
20016286 GOA
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
24338362 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11559703 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11864573 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPM1F 蛋白结构

PP2C

PP2C: Protein phosphatase 2C (158 - 406)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

protein phosphatase 1F

Ca(2+)/calmodulin-dependent protein kinase phosphatase

PPM1F 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPM1F P49593 FEM1B Homo sapiens Q9UK73
Anti Tag CoIP
11559703
种属间
PPM1F P49593 Camkk2 Mus musculus Q8C078
Anti Tag CoIP
15140879
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Sclerosing Cholangitis

Fibrosing Cholangitis

Cholangitis, Sclerosing

Primary Sclerosing Cholangitis
Hermaphroditism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10964 PPM1F Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPM1F VGNC VGNC:33212
Felis catus PPM1F VGNC VGNC:64311
Canis familiaris PPM1F VGNC VGNC:44866
Macaca mulatta PPM1F VGNC VGNC:76075
Rattus norvegicus PPM1F RGD RGD:631363
Mus musculus PPM1F MGD MGI:1918464
Others PPM1F NCBI
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