2. Gene
  3. DHRS9 - dehydrogenase/reductase 9 Gene

DHRS9 - dehydrogenase/reductase 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱氢酶/还原酶 9

种属: Homo sapiens

同用名: RDHL; RDH15; RDH-E2; RDHTBE; SDR9C4; RDH-TBE; RETSDR8; 3ALPHA-HSD; 3-alpha-HSD

基因 ID: 10170 | 基因类型: protein coding

关于 DHRS9

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,067,077-169,096,167 (from NCBI)

This gene has 9 transcripts (splice variants), 268 orthologues and 25 paralogues. Biased expression in colon (RPKM 23.4), esophagus (RPKM 9.8) and 12 other tissues.

功能概要

该基因编码短链脱氢酶/还原酶 (SDR) 家族的成员。编码的蛋白质已被确定为基于其执行机械不同功能的能力的兼职蛋白质。这种蛋白质对羟基类固醇具有氧化还原酶活性，能够在细胞质中将 3-α-四氢孕酮转化为二羟孕酮，将 3-α-雄烷二醇转化为二羟孕酮，并且还可以在细胞核中充当转录抑制因子。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

DHRS9 基因产物(5)

mRNA Protein Name
NM_001142270.2 NP_001135742.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001142271.2 NP_001135743.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_001289763.2 NP_001276692.1 dehydrogenase/reductase SDR family member 9 isoform 2
NM_001376924.1 NP_001363853.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
NM_199204.2 NP_954674.1 dehydrogenase/reductase SDR family member 9 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alcohol dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
11304534 GOA
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
11304534 GOA
enables androstan-3-alpha,17-beta-diol dehydrogenase activity IDA
IDA: 通过直接分析推断
11294878 GOA
enables androsterone dehydrogenase activity IDA
IDA: 通过直接分析推断
11294878 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables testosterone dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
11294878 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 9-cis-retinoic acid biosynthetic process IDA
IDA: 通过直接分析推断
11304534 GOA
involved in androgen metabolic process IDA
IDA: 通过直接分析推断
11294878 GOA
involved in progesterone metabolic process IDA
IDA: 通过直接分析推断
11294878 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
11294878 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DHRS9 蛋白结构

adh_short

adh_short: short chain dehydrogenase (31 - 193)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

dehydrogenase/reductase SDR family member 9

3-alpha hydroxysteroid dehydrogenase

重组 DHRS9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76871 DHRS9 Protein, Human (His) Q9BPW9 (R18-V319) ≥95%

关联疾病

疾病名称 别名
Smith-Lemli-Opitz Syndrome

SLOS

Rsh Syndrome

7-Dehydrocholesterol Reductase Deficiency

Slo Syndrome

Rutledge Lethal Multiple Congenital Anomaly Syndrome

Lethal Acrodysgenital Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung

Smith-Opitz-Inborn Syndrome

Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung

Smith Lemli Opitz Syndrome

Smith-Lemli-Opitz Syndrome, Type Ii
Postpartum Depression

Maternity Blues

Postnatal Depression

Depression, Postpartum

Post-Partum Depression

Depression Postpartum
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03745 DHRS9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DHRS9 VGNC VGNC:80180
Mus musculus DHRS9 MGD MGI:2442798
Macaca mulatta DHRS9 VGNC VGNC:71636
Bos taurus DHRS9 VGNC VGNC:28046
Canis familiaris DHRS9 VGNC VGNC:39937
Rattus norvegicus DHRS9 RGD RGD:620655
Others DHRS9 NCBI
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