2. Gene
  3. PRMT3 - protein arginine methyltransferase 3 Gene

PRMT3 - protein arginine methyltransferase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白质精氨酸甲基转移酶 3

种属: Homo sapiens

同用名: HRMT1L3

基因 ID: 10196 | 基因类型: protein coding

关于 PRMT3

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:20,387,716-20,509,338 (from NCBI)

This gene has 6 transcripts (splice variants), 205 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 7.5), brain (RPKM 3.3) and 25 other tissues.

功能概要

该基因属于蛋白质精氨酸甲基转移酶 (PRMT) 家族。编码的酶催化蛋白质精氨酰残基的胍基氮甲基化。该酶作用于 40S 核糖体蛋白 S2 (rpS2) ，这是其主要的体内底物，并参与 80S 核糖体的适当成熟。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 8 月]

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

PRMT3 基因产物(6)

mRNA Protein Name
XM_047426227.1 XP_047282183.1 protein arginine N-methyltransferase 3 isoform X1
NM_001145166.2 NP_001138638.1 protein arginine N-methyltransferase 3 isoform 2
NM_005788.4 NP_005779.1 protein arginine N-methyltransferase 3 isoform 1
XM_011519836.3 XP_011518138.1 protein arginine N-methyltransferase 3 isoform X2
XM_047426228.1 XP_047282184.1 protein arginine N-methyltransferase 3 isoform X3
NM_001145167.2 NP_001138639.1 protein arginine N-methyltransferase 3 isoform 3

PRMT3 蛋白结构

PrmA

PrmA: Ribosomal protein L11 methyltransferase (PrmA) (255 - 328)

  • 0
  • 100
  • 200
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  • 500
  • 531 a.a.
蛋白主名 其他名称

protein arginine N-methyltransferase 3

HMT1 hnRNP methyltransferase-like 3

heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

重组 PRMT3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76551 PRMT3 Protein, Human (His) O60678-1 (C2-Q531) ≥95%

关联疾病

疾病名称 别名
Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2

DRS2

Robinow, Autosomal Dominant Syndrome, Type 2
Oculopharyngeal Muscular Dystrophy

OPMD

Muscular Dystrophy, Oculopharyngeal

Dystrophy, Oculopharyngeal Muscular

Oculopharyngeal Dystrophy

Progressive Muscular Dystrophy, Oculopharyngeal Type

Muscular Dystrophy Oculopharyngeal

Dystrophy, Muscular, Oculopharyngeal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19615 MS023 Inhibitor 99.73% 否
HY-19715 SGC707 Inhibitor 98.08% 否
HY-19615B MS023 dihydrochloride Inhibitor 99.78% 否
HY-128717B GSK3368715 trihydrochloride Inhibitor / 否
HY-146810 PRMT4-IN-1 Inhibitor / 否
HY-110158 UNC2327 Inhibitor 99.70% 否
HY-159728 PROTAC PRMT3 degrader 1 Degrader / 否
HY-161334 CARM1-IN-4 Inhibitor / 否
HY-159732 PRMT3-IN-4 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PRMT3 VGNC VGNC:64359
Mus musculus PRMT3 MGD MGI:1919224
Rattus norvegicus PRMT3 RGD RGD:620413
Bos taurus PRMT3 VGNC VGNC:33349
Canis familiaris PRMT3 VGNC VGNC:44997
Others PRMT3 NCBI
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