2. Gene
  3. ABCC4 - ATP binding cassette subfamily C member 4 Gene

ABCC4 - ATP binding cassette subfamily C member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 C 成员 4

种属: Homo sapiens

同用名: MRP4; MOATB; MOAT-B

基因 ID: 10257 | 基因类型: protein coding

关于 ABCC4

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:95,019,835-95,301,451 (from NCBI)

This gene has 16 transcripts (splice variants), 461 orthologues and 11 paralogues. Broad expression in prostate (RPKM 22.4), urinary bladder (RPKM 9.3) and 16 other tissues.

功能概要

由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。该蛋白是参与多药耐药性的 MRP 亚家族的成员。该家族成员作为其底物有机阴离子的泵在细胞解毒中发挥作用。它还可能在纤毛发生中前列腺素介导的 cAMP 信号传导中发挥作用。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2014 年 9 月]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

ABCC4 基因产物(4)

mRNA Protein Name
NM_001105515.3 NP_001098985.1 ATP-binding cassette sub-family C member 4 isoform 2
NM_001301829.2 NP_001288758.1 ATP-binding cassette sub-family C member 4 isoform 3
NM_001301830.2 NP_001288759.1 ATP-binding cassette sub-family C member 4 isoform 4
NM_005845.5 NP_005836.2 ATP-binding cassette sub-family C member 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ABC-type bile acid transporter activity IMP
IMP: 通过突变表型推断
16282361 GOA
enables ABC-type glutathione S-conjugate transporter activity IDA
IDA: 通过直接分析推断
17959747 GOA
enables ATPase-coupled transmembrane transporter activity IDA
IDA: 通过直接分析推断
15364914 GOA
enables efflux transmembrane transporter activity IMP
IMP: 通过突变表型推断
25986174 GOA
enables glutathione transmembrane transporter activity IMP
IMP: 通过突变表型推断
11856762 GOA
enables guanine nucleotide transmembrane transporter activity IDA
IDA: 通过直接分析推断
15454390 GOA
enables prostaglandin transmembrane transporter activity IMP
IMP: 通过突变表型推断
15364914 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22411990 GOA
enables purine nucleotide transmembrane transporter activity IMP
IMP: 通过突变表型推断
25986174 GOA
enables urate transmembrane transporter activity IMP
IMP: 通过突变表型推断
15454390 GOA
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
11856762 GOA
enables xenobiotic transmembrane transporter activity IMP
IMP: 通过突变表型推断
25986174 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bile acid and bile salt transport IMP
IMP: 通过突变表型推断
16282361 GOA
involved in cAMP transport IDA
IDA: 通过直接分析推断
11856762 GOA
involved in cAMP transport IMP
IMP: 通过突变表型推断
25986174 GOA
acts upstream of or within cilium assembly IMP
IMP: 通过突变表型推断
25173977 GOA
involved in export across plasma membrane IMP
IMP: 通过突变表型推断
25986174 GOA
involved in leukotriene transport IDA
IDA: 通过直接分析推断
17959747 GOA
acts upstream of or within prostaglandin secretion IDA
IDA: 通过直接分析推断
25173977 GOA
involved in prostaglandin transport IMP
IMP: 通过突变表型推断
15364914 GOA
involved in urate transport IMP
IMP: 通过突变表型推断
15454390 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11856762 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
24130369 GOA
located in membrane IDA
IDA: 通过直接分析推断
15297306 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15297306 GOA
located in platelet dense granule membrane IDA
IDA: 通过直接分析推断
15297306 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABCC4 蛋白结构

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (93 - 358)

ABC_tran

ABC_tran: ABC transporter (428 - 562)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (715 - 991)

ABC_tran

ABC_tran: ABC transporter (1058 - 1205)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1325 a.a.
蛋白主名 其他名称

ATP-binding cassette sub-family C member 4

MRP/cMOAT-related ABC transporter

ABCC4 抗体

目录号 产品名 应用 反应物种
HY-P81421 MRP4 Antibody (YA1166) IHC-P Human

关联疾病

疾病名称 别名
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Dubin-Johnson Syndrome

DJS

Chronic Idiopathic Jaundice

Jaundice, Chronic Idiopathic

Hyperbilirubinemia, Dubin-Johnson Type

Hyperbilirubinemia Ii

Hyperbilirubinemia Type 2

Conjugated Hyperbilirubinemia

Dubin-Sprinz Disease

Sprinz-Nelson Syndrome

Hblrdj

Dubin Johnson Syndrome

Hyperbilirubinemia 2

Black Liver-Jaundice Syndrome

Chronic Idiopathic Jaundice With Pigmented Liver

Dubin-Sprinz Syndrome

Hyperbilirubinaemia Type 2

Djs - [Dubin-Johnson Syndrome]
Hyperuricemia

Blood Urate Raized

Uricacidemia
Fanconi-Like Syndrome

Fanconi Like Syndrome
Thiopurines, Poor Metabolism Of, 1

Thiopurine S-Methyltransferase Deficiency

Tpmt Deficiency

Thiopurine Methyltransferase Deficiency

Thiopurine S Methyltranferase Deficiency

THPM1

Tpmtd

Poor Metabolism Of Thiopurines-1

6-Mercaptopurine Sensitivity

Thiopurines, Poor Metabolism Of

Poor Metabolism Of Thiopurines
Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis

BRIC1

Summerskill Syndrome

Bric

Summerskill-Walshe-Tygstrup Syndrome

Cholestasis, Benign Recurrent Intrahepatic

Benign Recurrent Intrahepatic Cholestasis 1

Benign Recurrent Intrahepatic Cholestasis Type 1

Bric Type 1

Low Gamma-Gt Familial Intrahepatic Cholestasis

Recurrent Familial Intrahepatic Cholestasis

Cholestasis, Benign Recurrent Intrahepatic 1

Mild Atp8b1 Deficiency

Recurrent Familial Intrahepatic Cholestasis 1

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3

Bric - [Benign Recurrent Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 2

PFIC2

Cholestasis, Progressive Familial Intrahepatic 2

Progressive Familial Intrahepatic Cholestasis Type 2

Progressive Familial Intrahepatic Cholestasis 2

Bsep Deficiency

Recurrent Familial Intrahepatic Cholestasis 2

Benign Recurrent Intrahepatic Cholestasis 2

Severe Abcb11 Deficiency

Bric2

Cholestasis, Benign Recurrent Intrahepatic 2

Mild Abcb11 Deficiency

Cholestasis, Intrahepatic, Familial, Progressive, Type 2
Intrahepatic Cholestasis Of Pregnancy

Recurrent Intrahepatic Cholestasis Of Pregnancy

Gravidic Intrahepatic Cholestasis

Pregnancy-Related Cholestasis

Icp

Pregnancy Related Cholestasis

Cholestasis, Intrahepatic Of Pregnancy

Familial Intrahepatic Cholestasis Of Pregnancy

Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

Ricp

Obstetric Cholestasis
Progressive Familial Intrahepatic Cholestasis

Abcb4-Related Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic

Pfic

Byler Disease

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Bsep Deficiency

Byler Disease

Byler Syndrome

Fic1 Deficiency

Low Γ-Gt Familial Intrahepatic Cholestasis

Mdr3 Deficiency

Pfic

Cholestasis, Intrahepatic, Familial, Progressive

Pfic - [Progressive Familial Intrahepatic Cholestasis]
Cholestasis, Progressive Familial Intrahepatic, 3

PFIC3

Cholestasis, Progressive Familial Intrahepatic 3

Mdr3 Deficiency

Progressive Familial Intrahepatic Cholestasis Type 3

Progressive Familial Intrahepatic Cholestasis 3

Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gamma-Glutamyltransferase

Cholestasis, Progressive Familial Intrahepatic, With Elevated Serum Gamma-Glutamyltransferase

Progressive Familial Intrahepatic Cholestasis With Elevated Serum Gama-Glutamyltransferase

Cholestasis, Intrahepatic, Familial, Progressive, Type 3
Bilirubin Metabolic Disorder

Hyperbilirubinemia

Hereditary Hyperbilirubinemia

Hyperbilirubinemia, Hereditary

Hyperbilirubinaemia
Fanconi Syndrome

Infantile Nephropathic Cystinosis

Adult Fanconi Syndrome

Congenital Fanconi Syndrome

De Toni-Fanconi Syndrome

Fanconi-De Toni Syndrome

Lignac-Fanconi Syndrome

Fanconi Renotubular Syndrome

Primary Fanconi Renotubular Syndrome

De Toni-Debre-Fanconi Syndrome

Adult Fanconi Anemia

Detoni Fanconi Syndrome

Fanconi-De-Toni Syndrome

Primary Fanconi Syndrome

Detoni-Debre-Fanconi Syndrome

Primary Fanconi Renal Syndrome

Fanconi Anemia

Cystinosis, Infantile Nephropathic

Fanconi-Bickel Syndrome

Renal Fanconi Syndrome

Lowe-Bickel Syndrome
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19989A MK-571 sodium 99.75% 否
HY-129764 Prostaglandin F3α Substrate / 否
HY-RS00063 ABCC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ABCC4 MGD MGI:2443111
Canis familiaris ABCC4 VGNC VGNC:37441
Macaca mulatta ABCC4 VGNC VGNC:69573
Felis catus ABCC4 VGNC VGNC:67718
Rattus norvegicus ABCC4 RGD RGD:620266
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