2. Gene
  3. TRAIP - TRAF interacting protein Gene

TRAIP - TRAF interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TRAF 相互作用蛋白

种属: Homo sapiens

同用名: TRIP; SCKL9; RNF206

基因 ID: 10293 | 基因类型: protein coding

关于 TRAIP

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,828,601-49,856,564 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and is associated with 3 phenotypes. Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues.

功能概要

该基因编码的蛋白质包含一个 N 端环指基序和一个假定的卷曲螺旋结构域。一种类似的鼠类蛋白质与 TNFR 相关因子 1 (TRAF1) 、TNFR 相关因子 2 (TRAF2) 和圆柱瘤病相互作用。与 TRAF2 的相互作用抑制 TRAF2 介导的核因子 kappa-B，这是细胞活化和防止细胞凋亡所需的亚基 1 活化。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against Apoptosis. [provided by RefSeq, Jul 2008]

TRAIP 基因产物(1)

mRNA Protein Name
NM_005879.3 NP_005870.2 E3 ubiquitin-protein ligase TRAIP
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
17544371 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
26711499 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
19151749 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
17544371 GOA
involved in replication fork processing IDA
IDA: 通过直接分析推断
26711499 GOA
involved in replication fork processing IMP
IMP: 通过突变表型推断
27462463 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
27462463 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
30165463 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
26711499 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAIP 蛋白结构

zf-RING_2

zf-RING_2: Ring finger domain (7 - 50)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRAIP

RING-type E3 ubiquitin transferase TRAIP

TRAIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra TRAIP Q9BWF2 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Validated Y2H
25416956
Intra TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Array
32296183
Intra TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
25416956
Intra TRAIP Q9BWF2 MAPRE2 Homo sapiens Q15555
Y2H Prey Pooling
32296183
Intra TRAIP Q9BWF2 ccsb_9919 Homo sapiens EBI-25847655
Y2H Array
32814053
Intra TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra TRAIP Q9BWF2 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra TRAIP Q9BWF2 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Seckel Syndrome 9

SCKL9
Seckel Syndrome

Microcephalic Primordial Dwarfism

Bird-Headed Dwarfism

Harper'S Syndrome

Virchow-Seckel Dwarfism

Nanocephalic Dwarfism

Sckl

Seckel-Type Dwarfism
Inflammatory Bowel Disease 9

IBD9
Meier-Gorlin Syndrome 8

MGORS8
Deafness, Autosomal Dominant 70

DFNA70

Autosomal Dominant Nonsyndromic Deafness 70

Autosomal Dominant Deafness 70

Deafness, Autosomal Dominant, 70
Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS
Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign
Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia

Primordial Dwarfism

Isolated Growth Hormone Deficiency Type Ia

Sexual Ateleiotic Dwarfism

Pituitary Dwarfism I

IGHD1A

Illig-Type Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, Type Ia

Congenital Ighd Type Ia

Congenital Isolated Gh Deficiency Type Ia

Congenital Isolated Growth Hormone Deficiency Type Ia

Pituitary Dwarfism 1

Growth Hormone Deficiency, Isolated, Autosomal Recessive

Autosomal Recessive Isolated Growth Hormone Deficiency

Isolated Growth Hormone Deficiency Type 1a

Congenital Ighd

Congenital Isolated Gh Deficiency

Congenital Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated Autosomal Recessive

Illig Type Growth Hormone Deficiency

Non-Acquired Isolated Growth Hormone Deficiency

Growth Hormone Deficiency, Isolated, 1a

Growth Hormone Deficiency Isolated Autosomal Recessive

Dwarfism, Primordial

Dwarfism
Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome

Spiegler-Brooke Syndrome

Familial Cylindromatosis

BRSS

Bss

Sbs

Multiple Familial Trichoepithelioma

Ancell-Spiegler Cylindromas

Familial Multiple Trichoepithelioma

Trichoepithelioma

Fc

Mft

Multiple Familial Trichoepitheliomas

Ccs

Turban Tumor Syndrome

Schilbach-Rott Syndrome

Eccrine Dermal Cylindroma

Familial Multiple Trichoepitheliomata
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14978 TRAIP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRAIP MGD MGI:1096377
Felis catus TRAIP VGNC VGNC:66504
Macaca mulatta TRAIP VGNC VGNC:82261
Bos taurus TRAIP VGNC VGNC:36280
Canis familiaris TRAIP VGNC VGNC:47772
Rattus norvegicus TRAIP RGD RGD:1309761
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