2. Gene
  3. DLC1 - DLC1 Rho GTPase activating protein Gene

DLC1 - DLC1 Rho GTPase activating protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DLC1 Rho GTP 酶激活蛋白

种属: Homo sapiens

同用名: HP; ARHGAP7; STARD12; p122-RhoGAP

基因 ID: 10395 | 基因类型: protein coding

关于 DLC1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:13,083,361-13,604,620 (from NCBI)

This gene has 18 transcripts (splice variants), 205 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 21.4), fat (RPKM 12.0) and 21 other tissues.

功能概要

该基因编码一种 GTP 酶激活蛋白 (GAP) ，它是 rhoGAP 蛋白家族的一员，在调节小 GTP 结合蛋白方面发挥作用。 GAP 家族蛋白参与调节涉及细胞骨架变化的细胞过程的信号通路。该基因在许多常见癌症 (包括前列腺癌、肺癌、结直肠癌和乳腺癌) 中起抑癌基因的作用。由于替代启动子和可变剪接，已发现该基因的多个转录变体。[RefSeq 提供，2010 年 4 月]

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

DLC1 基因产物(26)

mRNA Protein Name
NM_001164271.2 NP_001157743.1 rho GTPase-activating protein 7 isoform 4
NM_001316668.2 NP_001303597.1 rho GTPase-activating protein 7 isoform 5
NM_001348081.2 NP_001335010.1 rho GTPase-activating protein 7 isoform 1
NM_001348082.2 NP_001335011.1 rho GTPase-activating protein 7 isoform 4
NM_001348083.1 NP_001335012.1 rho GTPase-activating protein 7 isoform 4
NM_001348084.2 NP_001335013.1 rho GTPase-activating protein 7 isoform 4
NM_001413124.1 NP_001400053.1 rho GTPase-activating protein 7 isoform 1
NM_001413125.1 NP_001400054.1 rho GTPase-activating protein 7 isoform 14
NM_001413126.1 NP_001400055.1 rho GTPase-activating protein 7 isoform 4
NM_001413127.1 NP_001400056.1 rho GTPase-activating protein 7 isoform 4
NM_001413128.1 NP_001400057.1 rho GTPase-activating protein 7 isoform 4
NM_001413129.1 NP_001400058.1 rho GTPase-activating protein 7 isoform 6
NM_001413130.1 NP_001400059.1 rho GTPase-activating protein 7 isoform 7
NM_001413131.1 NP_001400060.1 rho GTPase-activating protein 7 isoform 8
NM_001413132.1 NP_001400061.1 rho GTPase-activating protein 7 isoform 9
NM_001413133.1 NP_001400062.1 rho GTPase-activating protein 7 isoform 4
NM_001413134.1 NP_001400063.1 rho GTPase-activating protein 7 isoform 10
NM_001413135.1 NP_001400064.1 rho GTPase-activating protein 7 isoform 11
NM_001413136.1 NP_001400065.1 rho GTPase-activating protein 7 isoform 12
NM_001413137.1 NP_001400066.1 rho GTPase-activating protein 7 isoform 8
NM_001413138.1 NP_001400067.1 rho GTPase-activating protein 7 isoform 4
NM_001413139.1 NP_001400068.1 rho GTPase-activating protein 7 isoform 15
NM_001413140.1 NP_001400069.1 rho GTPase-activating protein 7 isoform 16
NM_006094.5 NP_006085.2 rho GTPase-activating protein 7 isoform 2
NM_024767.5 NP_079043.3 rho GTPase-activating protein 7 isoform 3
NM_182643.3 NP_872584.2 rho GTPase-activating protein 7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables GTPase activator activity IDA
IDA: 通过直接分析推断
17932950 GOA
enables GTPase activator activity IMP
IMP: 通过突变表型推断
17888903 GOA
enables SH2 domain binding IPI
IPI: 通过物理相互作用推断
17190795 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16951145 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
17888903 GOA
involved in apoptotic process IDA
IDA: 通过直接分析推断
17292327 GOA
involved in negative regulation of Rho protein signal transduction IMP
IMP: 通过突变表型推断
16951145 GOA
involved in negative regulation of cell migration IDA
IDA: 通过直接分析推断
17932950 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
17292327 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12545165 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17292327 GOA
involved in negative regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
19158340 GOA
involved in negative regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
17932950 GOA
involved in positive regulation of execution phase of apoptosis IDA
IDA: 通过直接分析推断
17888903 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
17292327 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
17292327 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
16951145 GOA
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
19158340 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16951145 GOA
located in cytosol IDA
IDA: 通过直接分析推断
19158340 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
16951145 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17888903 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
19158340 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DLC1 蛋白结构

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (454 - 513)

RhoGAP

RhoGAP: RhoGAP domain (1092 - 1236)

START

START: START domain (1326 - 1522)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1528 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 7

Rho-GTPase-activating protein 7

DLC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Y2H
19151751
种属内
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Y2H Array
24412244
种属内
DLC1 Q96QB1 RASA1 Homo sapiens P20936
Anti Tag CoIP
19151751
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03793 DLC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DLC1 RGD RGD:68416
Macaca mulatta DLC1 VGNC VGNC:83993
Mus musculus DLC1 MGD MGI:1354949
Felis catus DLC1 VGNC VGNC:61509
Canis familiaris DLC1 VGNC VGNC:39975
Bos taurus DLC1 VGNC VGNC:28084
Others DLC1 NCBI
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