1. Gene
  2. AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

中文名称:1-酰基甘油-3-磷酸 O-酰基转移酶 1

种属: Homo sapiens

同用名: G15; LPAATA; LPLAT1; 1-AGPAT1; LPAAT-alpha

基因 ID: 10554 | 基因类型: protein coding

关于 AGPAT1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,168,212-32,178,108 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 139 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 25.5), brain (RPKM 21.6) and 25 other tissues.

功能概要

该基因编码一种将溶血磷脂酸 (LPA) 转化为磷脂酸 (PA) 的酶。 LPA 和 PA 是参与信号转导和细胞脂质生物合成的两种磷脂。该酶定位于内质网。该基因位于人类主要组织相容性复合体的 III 类区域。可变剪接导致编码相同蛋白质的两个转录变体。[RefSeq 提供,2008 年 7 月]

This gene encodes an Enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two Phospholipids involved in signal transduction and in lipid biosynthesis in cells. This Enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AGPAT1 基因产物(5)

mRNA Protein Name
NM_001371437.1 NP_001358366.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2
NM_001371438.1 NP_001358367.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_001371439.1 NP_001358368.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_006411.4 NP_006402.1 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_032741.5 NP_116130.2 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: 通过直接分析推断
9461603 GOA
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IGI
IGI: 通过遗传相互作用推断
9212163 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in phosphatidic acid biosynthetic process IGI
IGI: 通过遗传相互作用推断
9212163 GOA
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
9212163 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
9461603 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AGPAT1 蛋白结构

Acyltransferase

Acyltransferase: Acyltransferase (83 - 211)

  • 0
  • 100
  • 200
  • 283 a.a.
蛋白主名 其他名称

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1-AGP acyltransferase 1

AGPAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AGPAT1 Q99943 MEOX2 Homo sapiens P50222 25416956
种属内
AGPAT1 Q99943 RNASEH2A Homo sapiens O75792 33961781
种属内
AGPAT1 Q99943 RNASEH2A Homo sapiens O75792 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lipodystrophy, Congenital Generalized, Type 1

Congenital Generalized Lipodystrophy Type 1

Bscl1

CGL1

Berardinelli-Seip Congenital Lipodystrophy, Type 1

Brunzell Syndrome Agpat2-Related

Berardinelli-Seip Congenital Lipodystrophy Type 1

Lipodystrophy, Berardinelli-Seip Congenital, Type 1

Brunzell Syndrome, Agpat2-Related

Agpat2-Related Brunzell Syndrome

Congenital Generalized Lipodystrophy 1

Berardinelli-Seip Syndrome

Lipoatrophic Diabetes

Lipodystrophy Berardinelli Type

Total Lipodystrophy And Acromegaloid Gigantism

Lipodystrophy, Generalized, Congenital, Type 1

Familial Generalized Lipodystrophy

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2

Complete Generalized Lipodystrophy
Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2

CGL2

Berardinelli-Seip Congenital Lipodystrophy Type 2

Berardinelli-Seip Syndrome

Brunzell Syndrome Bscl2-Related

Total Lipodystrophy And Acromegaloid Gigantism

Berardinelli-Seip Congenital Lipodystrophy, Type 2

Seip Syndrome

Berardinelli Syndrome

Lipodystrophy, Total, And Acromegaloid Gigantism

Lipoatrophic Diabetes, Congenital

Lipodystrophy, Berardinelli-Seip Congenital, Type 2

Brunzell Syndrome, Bscl2-Related

Congenital Lipoatrophic Diabetes

Congenital Generalized Lipodystrophy 2

Lipoatrophic Diabetes

Lipodystrophy Berardinelli Type

Familial Generalized Lipodystrophy

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy

Berardinelli-Seip Syndrome

Brunzell Syndrome

Bscl

Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized

Seip Syndrome

Total Lipodystrophy

Cgl

Lipoatrophic Diabetes

Lipodystrophy, Generalized, Congenital

Familial Generalized Lipodystrophy

Congenital Generalized Lipodystrophy Type 2

Lipoatrophic Diabetes Mellitus

Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence

Fads

Fetal Akinesia Sequence

FADS1

Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia

Pena-Shokeir Syndrome Type 1

Fetal Akinesia Deformation Sequence Syndrome

Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome

Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia

Pena-Shokeir Syndrome, Type I

Foetal Akinesia Deformation Sequence Syndrome

Foetal Akinesia Sequence

Fetal Akinesia Deformation Sequence Syndrome 1

Pena-Shokeir Syndrome, Type 1

Pena Shokeir Syndrome, Type 1

Akinesia, Fetal, Deformation Sequence

Akinesia, Fetal, Deformation Sequence, Type 1

Pena-Shokeir Syndrome Type I

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus AGPAT1 VGNC VGNC:25734
Mus musculus AGPAT1 MGD MGI:1932075
Canis familiaris AGPAT1 VGNC VGNC:37710
Felis catus AGPAT1 VGNC VGNC:102377
Macaca mulatta AGPAT1 VGNC VGNC:69745
Rattus norvegicus AGPAT1 RGD RGD:1303287