AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

中文名称：1-酰基甘油-3-磷酸 O-酰基转移酶 1

种属: Homo sapiens

同用名: G15; LPAATA; LPLAT1; 1-AGPAT1; LPAAT-alpha

基因 ID: 10554 | 基因类型: protein coding

关于 AGPAT1

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,168,212-32,178,108 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 139 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 25.5), brain (RPKM 21.6) and 25 other tissues.

功能概要

该基因编码一种将溶血磷脂酸 (LPA) 转化为磷脂酸 (PA) 的酶。 LPA 和 PA 是参与信号转导和细胞脂质生物合成的两种磷脂。该酶定位于内质网。该基因位于人类主要组织相容性复合体的 III 类区域。可变剪接导致编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an Enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two Phospholipids involved in signal transduction and in lipid biosynthesis in cells. This Enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

AGPAT1 基因产物(5)

mRNA	Protein	Name
NM_001371437.1	NP_001358366.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 2
NM_001371438.1	NP_001358367.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_001371439.1	NP_001358368.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_006411.4	NP_006402.1	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor
NM_032741.5	NP_116130.2	1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IDA IDA: 通过直接分析推断	9461603	GOA
enables 1-acylglycerol-3-phosphate O-acyltransferase activity	IGI IGI: 通过遗传相互作用推断	9212163	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in phosphatidic acid biosynthetic process	IGI IGI: 通过遗传相互作用推断	9212163	GOA
involved in positive regulation of cytokine production	IMP IMP: 通过突变表型推断	9212163	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	9461603	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGPAT1 蛋白结构

Acyltransferase

0
100
200
283 a.a.

蛋白主名

其他名称

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1-AGP acyltransferase 1

AGPAT1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AGPAT1	Q99943	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
种属内	AGPAT1	Q99943	RNASEH2A	Homo sapiens	O75792	Anti Tag CoIP	33961781
种属内	AGPAT1	Q99943	RNASEH2A	Homo sapiens	O75792	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lipodystrophy, Congenital Generalized, Type 1

Congenital Generalized Lipodystrophy Type 1	Bscl1
CGL1	Berardinelli-Seip Congenital Lipodystrophy, Type 1
Brunzell Syndrome Agpat2-Related	Berardinelli-Seip Congenital Lipodystrophy Type 1
Lipodystrophy, Berardinelli-Seip Congenital, Type 1	Brunzell Syndrome, Agpat2-Related
Agpat2-Related Brunzell Syndrome	Congenital Generalized Lipodystrophy 1
Berardinelli-Seip Syndrome	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Total Lipodystrophy And Acromegaloid Gigantism
Lipodystrophy, Generalized, Congenital, Type 1	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Complete Generalized Lipodystrophy

Lipodystrophy, Congenital Generalized, Type 2

Congenital Generalized Lipodystrophy Type 2	CGL2
Berardinelli-Seip Congenital Lipodystrophy Type 2	Berardinelli-Seip Syndrome
Brunzell Syndrome Bscl2-Related	Total Lipodystrophy And Acromegaloid Gigantism
Berardinelli-Seip Congenital Lipodystrophy, Type 2	Seip Syndrome
Berardinelli Syndrome	Lipodystrophy, Total, And Acromegaloid Gigantism
Lipoatrophic Diabetes, Congenital	Lipodystrophy, Berardinelli-Seip Congenital, Type 2
Brunzell Syndrome, Bscl2-Related	Congenital Lipoatrophic Diabetes
Congenital Generalized Lipodystrophy 2	Lipoatrophic Diabetes
Lipodystrophy Berardinelli Type	Familial Generalized Lipodystrophy
Lipoatrophic Diabetes Mellitus	Familial Partial Lipodystrophy, Type 2

Congenital Generalized Lipodystrophy

Berardinelli-Seip Congenital Lipodystrophy	Berardinelli-Seip Syndrome
Brunzell Syndrome	Bscl
Generalized Lipodystrophy	Lipodystrophy, Congenital Generalized
Seip Syndrome	Total Lipodystrophy
Cgl	Lipoatrophic Diabetes
Lipodystrophy, Generalized, Congenital	Familial Generalized Lipodystrophy
Congenital Generalized Lipodystrophy Type 2	Lipoatrophic Diabetes Mellitus
Familial Partial Lipodystrophy, Type 2

Fetal Akinesia Deformation Sequence 1

Fetal Akinesia Deformation Sequence	Fads
Fetal Akinesia Sequence	FADS1
Arthrogryposis Multiplex Congenita With Pulmonary Hypoplasia	Pena-Shokeir Syndrome Type 1
Fetal Akinesia Deformation Sequence Syndrome	Arthrogryposis Multiplex Congenita-Pulmonary Hypoplasia Syndrome
Arthrogryposis Multiplex Congenita Pulmonary Hypoplasia	Pena-Shokeir Syndrome, Type I
Foetal Akinesia Deformation Sequence Syndrome	Foetal Akinesia Sequence
Fetal Akinesia Deformation Sequence Syndrome 1	Pena-Shokeir Syndrome, Type 1
Pena Shokeir Syndrome, Type 1	Akinesia, Fetal, Deformation Sequence
Akinesia, Fetal, Deformation Sequence, Type 1	Pena-Shokeir Syndrome Type I

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00456	AGPAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	AGPAT1	VGNC	VGNC:25734
Mus musculus	AGPAT1	MGD	MGI:1932075
Canis familiaris	AGPAT1	VGNC	VGNC:37710
Felis catus	AGPAT1	VGNC	VGNC:102377
Macaca mulatta	AGPAT1	VGNC	VGNC:69745
Rattus norvegicus	AGPAT1	RGD	RGD:1303287

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

关于 AGPAT1

功能概要

AGPAT1 基因产物(5)

AGPAT1 蛋白结构

AGPAT1 蛋白互作信息

关联疾病

直系同源

热门区域

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AGPAT1 - 1-acylglycerol-3-phosphate O-acyltransferase 1 Gene

关于 AGPAT1

功能概要

AGPAT1 基因产物(5)

AGPAT1 蛋白结构

AGPAT1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z