2. Gene
  3. SLC34A2 - solute carrier family 34 member 2 Gene

SLC34A2 - solute carrier family 34 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 34 成员 2

种属: Homo sapiens

同用名: PULAM; NPTIIb; NAPI-3B; NAPI-IIb

基因 ID: 10568 | 基因类型: protein coding

关于 SLC34A2

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,655,851-25,678,748 (from NCBI)

This gene has 7 transcripts (splice variants), 296 orthologues, 2 paralogues and is associated with 75 phenotypes. Restricted expression toward lung (RPKM 380.9).

功能概要

该基因编码的蛋白质是一种 pH 敏感的钠依赖性磷酸盐转运蛋白。在较低的 pH 值下磷酸盐吸收增加。该基因的缺陷是肺泡微石症的一个原因。已发现该基因编码两种不同亚型的三种转录变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

SLC34A2 基因产物(3)

mRNA Protein Name
NM_001177998.2 NP_001171469.2 sodium-dependent phosphate transport protein 2B isoform b
NM_001177999.2 NP_001171470.2 sodium-dependent phosphate transport protein 2B isoform b
NM_006424.3 NP_006415.3 sodium-dependent phosphate transport protein 2B isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphate ion binding IDA
IDA: 通过直接分析推断
12488042 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sodium ion binding IDA
IDA: 通过直接分析推断
12488042 GOA
enables sodium:phosphate symporter activity IDA
IDA: 通过直接分析推断
10329428 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular phosphate ion homeostasis IDA
IDA: 通过直接分析推断
10610722 GOA
involved in phosphate ion transport IDA
IDA: 通过直接分析推断
10329428 GOA
involved in response to estrogen IEP
IEP: 通过表达模式推断
12893629 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15970207 GOA
located in membrane IDA
IDA: 通过直接分析推断
10329428 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC34A2 蛋白结构

Na_Pi_cotrans

Na_Pi_cotrans: Na+/Pi-cotransporter (110 - 233)

Na_Pi_cotrans

Na_Pi_cotrans: Na+/Pi-cotransporter (380 - 505)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
蛋白主名 其他名称

sodium-dependent phosphate transport protein 2B

sodium/phosphate cotransporter 2B

SLC34A2 抗体

目录号 产品名 应用 反应物种
HY-P81437 SLC34A2 Antibody (YA1182) IHC-P Human

关联疾病

疾病名称 别名
Pulmonary Alveolar Microlithiasis

PULAM

Pam
Testicular Microlithiasis
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Baritosis

Deposition Of Barium In The Lungs

Inhalation Of Barytes
Pulmonary Hemosiderosis

Idiopathic Pulmonary Hemosiderosis

Alveolar Hypoventilation Syndrome

Brown Induration

Brown Lung

Siderosis

Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin

Byssinosis
Hypophosphatemic Rickets With Hypercalciuria, Hereditary

Hereditary Hypophosphatemic Rickets With Hypercalciuria

HHRH

Hypophosphatemic Rickets With Hypercalciuria

Hypercalciuric Rickets
Chronic Congestive Splenomegaly
Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic

Bamberger-Marie Disease

Hpoa - Hypertrophic Pulmonary Osteoarthropathy

Hypertrophic Pulmonary Osteoarthropathy

Marie Bamberger Disease
Phosphorus Metabolism Disease

Phosphorus Metabolism Disorders

Disorder Of Phosphorus Metabolism

Phosphorus Disorder

Phosphorus Metabolism Disorder
Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V

Hyperchylomicronemia, Late-Onset

Familial Type 5 Hyperlipoproteinemia

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

Hyperlipidemia, Type V

Hyperlipemia, Mixed

Hyperlipemia, Combined Fat And Carbohydrate-Induced

Familial Hyperlipoproteinemia Type V

Fredrickson Type V Lipaemia

Hyperlipoproteinemia Type 5

Hyperchylomicronemia Late Onset

Hyperlipemia Combined Fat And Carbohydrate-Induced

Hyperlipemia Mixed

Hyperlipidemia Type V

Mixed Hyperlipemia

Type V Hyperlipoproteinemia

Hyperlipoproteinemia 5

HLPP5

Hyperlipidemia, Familial Combined

Mixed Hyperlipidemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145894 NaPi2b-IN-2 98.93% 否
HY-146429 NaPi2b-IN-3 Inhibitor / 否
HY-RS13193 SLC34A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLC34A2 VGNC VGNC:34818
Felis catus SLC34A2 VGNC VGNC:65317
Macaca mulatta SLC34A2 VGNC VGNC:77459
Mus musculus SLC34A2 MGD MGI:1342284
Rattus norvegicus SLC34A2 RGD RGD:620889
Canis familiaris SLC34A2 VGNC VGNC:46359
Macaca fascicularis SLC34A2 NCBI NCBI:102137752
Others SLC34A2 NCBI
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