CCT4 - chaperonin containing TCP1 subunit 4 Gene

中文名称：含伴侣蛋白的 TCP1 亚基 4

种属: Homo sapiens

同用名: SRB; Cctd; CCT-DELTA

基因 ID: 10575 | 基因类型: protein coding

关于 CCT4

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:61,868,085-61,888,671 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 13 paralogues. Ubiquitous expression in ovary (RPKM 58.5), testis (RPKM 51.7) and 25 other tissues.

功能概要

含有 TCP1 (MIM 186980) 复合物 (CCT) 的伴侣蛋白，也称为 TCP1 环复合物，由 2 个背靠背环组成，每个环包含 8 个独特但同源的亚基，例如 CCT4。 CCT 通过多轮 ATP 驱动的释放和部分折叠的中间形式的重新结合来协助新翻译的多肽底物的折叠。 CCT 的底物包括细胞骨架蛋白肌动蛋白 (参见 MIM 102560) 和微管蛋白 (参见 MIM 191130) ，以及α-转导蛋白 (MIM 139330) (Won 等人，1998 [PubMed 9819444]) 。[OMIM 提供，3 月 2008]

The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

CCT4 基因产物(2)

mRNA	Protein	Name
NM_001256721.1	NP_001243650.1	T-complex protein 1 subunit delta isoform b
NM_006430.4	NP_006421.2	T-complex protein 1 subunit delta isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16085932	GOA
enables protein folding chaperone	IDA IDA: 通过直接分析推断	25467444	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chaperone mediated protein folding independent of cofactor	IMP IMP: 通过突变表型推断	25467444	GOA
involved in chaperone-mediated protein folding	IDA IDA: 通过直接分析推断	22133715	GOA
involved in positive regulation of telomerase RNA localization to Cajal body	IMP IMP: 通过突变表型推断	25467444	GOA
acts upstream of positive regulation of telomere maintenance via telomerase	IMP IMP: 通过突变表型推断	25467444	GOA
involved in protein folding	IDA IDA: 通过直接分析推断	30955883	GOA
involved in protein stabilization	IMP IMP: 通过突变表型推断	25467444	GOA
acts upstream of positive effect scaRNA localization to Cajal body	IMP IMP: 通过突变表型推断	25467444	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centrosome	IDA IDA: 通过直接分析推断	20080638	GOA
part of chaperonin-containing T-complex	IDA IDA: 通过直接分析推断	23011926	GOA
part of chaperonin-containing T-complex	IPI IPI: 通过物理相互作用推断	22133715	GOA
located in microtubule	IDA IDA: 通过直接分析推断	21525035	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCT4 蛋白结构

Cpn60_TCP1

0
100
200
300
400
500
539 a.a.

蛋白主名

其他名称

T-complex protein 1 subunit delta

TCP-1-delta

CCT4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCT4	P50991	TCP1	Homo sapiens	P17987	Anti Tag CoIP	35271311
种属内	CCT4	P50991	CCT2	Homo sapiens	P78371	Anti Tag CoIP	35271311
种属内	CCT4	P50991	CCT2	Homo sapiens	P78371	Validated Y2H	32296183
种属内	CCT4	P50991	OLR1	Homo sapiens	P78380	Pull Down	24846140
种属内	CCT4	P50991	CCNH	Homo sapiens	P51946	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Sensory Peripheral Neuropathy

Sensory Neuropathy	Peripheral Sensory Neuropathy
Hereditary Sensory And Autonomic Neuropathies

Posterior Cerebral Artery Infarction

Infarction, Posterior Cerebral Artery

Peroxisome Biogenesis Disorder 11a

PBD11A	Peroxisome Biogenesis Disorder Complementation Group 13
PBD-CG13	Cg13
Pbd-Cgh	Peroxisome Biogenesis Disorder Complementation Group H
Peroxisome Biogenesis Disorder, Type 11a	Peroxisome Biogenesis Disorder, Complementation Group 13

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02181	CCT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CCT4	VGNC	VGNC:26997
Felis catus	CCT4	VGNC	VGNC:60578
Canis familiaris	CCT4	VGNC	VGNC:38924
Mus musculus	CCT4	MGD	MGI:104689
Macaca mulatta	CCT4	VGNC	VGNC:70747
Rattus norvegicus	CCT4	RGD	RGD:727937

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCT4 - chaperonin containing TCP1 subunit 4 Gene

关于 CCT4

功能概要

CCT4 基因产物(2)

CCT4 蛋白结构

CCT4 蛋白互作信息

关联疾病

直系同源

热门区域

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CCT4 - chaperonin containing TCP1 subunit 4 Gene

关于 CCT4

功能概要

CCT4 基因产物(2)

CCT4 蛋白结构

CCT4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z