1. Gene
  2. TCP1 - t-complex 1 Gene

TCP1 - t-complex 1 Gene

中文名称:t 复合物 1

种属: Homo sapiens

同用名: CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha

基因 ID: 6950 | 基因类型: protein coding

关于 TCP1

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:159,778,498-159,789,602 (from NCBI)

This gene has 18 transcripts (splice variants), 228 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 91.3), brain (RPKM 50.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种分子伴侣,它是含有伴侣蛋白的 TCP1 复合物 (CCT) 的成员,也称为 TCP1 环状复合物 (TRiC) 。该复合物由两个相同的堆叠环组成,每个环包含八种不同的蛋白质。未折叠的多肽进入复合物的中央空腔,并以依赖 ATP 的方式折叠。该复合物折叠各种蛋白质,包括肌动蛋白和微管蛋白。已经表征了该基因的替代转录剪接变体,编码不同的同种型。此外,还发现了三个似乎源自该基因的假基因。[RefSeq 提供,2010 年 6 月]

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]

TCP1 基因产物(2)

mRNA Protein Name
NM_001008897.2 NP_001008897.1 T-complex protein 1 subunit alpha isoform b
NM_030752.3 NP_110379.2 T-complex protein 1 subunit alpha isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14532270 GOA
enables protein folding chaperone IDA
IDA: 通过直接分析推断
25467444 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
21753002 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
20080638 GOA
part of chaperonin-containing T-complex IDA
IDA: 通过直接分析推断
23011926 GOA
part of chaperonin-containing T-complex IPI
IPI: 通过物理相互作用推断
22133715 GOA
located in microtubule IDA
IDA: 通过直接分析推断
21525035 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TCP1 蛋白结构

Cpn60_TCP1

Cpn60_TCP1: TCP-1/cpn60 chaperonin family (28 - 532)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 556 a.a.
蛋白主名 其他名称

T-complex protein 1 subunit alpha

T-complex protein 1, alpha subunit

TCP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110-2
Confocal
29477555
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110-2
ELISA
29477555
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110-2
MST
29477555
种属内
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2
Y2H Array
32814053
种属内
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2
Y2H Pooling
32814053
种属内
TCP1 P17987 BRPF3 Homo sapiens Q9ULD4-2
Validated Y2H
32814053
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110-1
MST
29477555
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110-1
ELISA
29477555
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110
Confocal
29477555
种属内
TCP1 P17987 HTRA3 Homo sapiens P83110
Anti Bait CoIP
29477555
种属内
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0
Y2H Pooling
32814053
种属内
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0
Validated Y2H
32814053
种属内
TCP1 P17987 ARL2BP Homo sapiens Q9Y2Y0
Y2H Array
32814053
种属内
TCP1 P17987 CCT8 Homo sapiens P50990
TAP
16085932
种属内
TCP1 P17987 CCT8 Homo sapiens P50990
Crosslink
30021884
种属内
TCP1 P17987 CCT4 Homo sapiens P50991
Crosslink
30021884
种属内
TCP1 P17987 CCT4 Homo sapiens P50991
TAP
16085932
种属内
TCP1 P17987 CCT2 Homo sapiens P78371
BN-PAGE
16097032
种属内
TCP1 P17987 CCT2 Homo sapiens P78371
TAP
16085932
种属内
TCP1 P17987 CCT2 Homo sapiens P78371
Crosslink
30021884
种属内
TCP1 P17987 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
TCP1 P17987 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
TCP1 P17987 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
TCP1 P17987 OLR1 Homo sapiens P78380
IF
24846140
种属内
TCP1 P17987 OLR1 Homo sapiens P78380
Pull Down
24846140
种属内
TCP1 P17987 CBFA2T2 Homo sapiens O43439
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 48

Mental Retardation, Autosomal Dominant 48

MRD48

Autosomal Dominant Mental Retardation 48

Autosomal Dominant Intellectual Developmental Disorder 48

Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TCP1 VGNC VGNC:66034
Macaca mulatta TCP1 VGNC VGNC:83494
Rattus norvegicus TCP1 RGD RGD:3832
Mus musculus TCP1 MGD MGI:98535
Bos taurus TCP1 VGNC VGNC:35701
Canis familiaris TCP1 VGNC VGNC:47207
Others TCP1 NCBI