2. Gene
  3. HTRA3 - HtrA serine peptidase 3 Gene

HTRA3 - HtrA serine peptidase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：HtrA 丝氨酸肽酶 3

种属: Homo sapiens

同用名: Prsp; Tasp

基因 ID: 94031 | 基因类型: protein coding

关于 HTRA3

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,269,754-8,307,098 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues.

功能概要

启用内肽酶活性；相同的蛋白质结合活性；和丝氨酸型肽酶活性。参与蛋白水解。预测位于细胞外区域。 [由基因组资源联盟提供，2022 年 4 月]

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

HTRA3 基因产物(2)

mRNA Protein Name
NM_001297559.3 NP_001284488.1 serine protease HTRA3 isoform 2 precursor
NM_053044.5 NP_444272.1 serine protease HTRA3 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
18387192 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26110759 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22229724 GOA
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
22229724 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in proteolysis IDA
IDA: 通过直接分析推断
18387192 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTRA3 蛋白结构

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (81 - 126)

Trypsin_2

Trypsin_2: Trypsin-like peptidase domain (175 - 319)

PDZ_2

PDZ_2: PDZ domain (356 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

serine protease HTRA3

high-temperature requirement factor A3

HTRA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HTRA3 P83110 HTRA4 Homo sapiens P83105
Anti Tag CoIP
25002585
种属内
HTRA3 P83110 HTRA3 Homo sapiens P83110
GMS
26110759
种属内
HTRA3 P83110 XIAP Homo sapiens P98170
Anti Bait CoIP
31260151
种属内
HTRA3 P83110 ACTB Homo sapiens P60709
Anti Bait CoIP
29477555
种属内
HTRA3 P83110 XIAP Homo sapiens P98170
PLA
31260151
种属内
HTRA3 P83110 XIAP Homo sapiens P98170
Pull Down
31260151
种属内
HTRA3 P83110 XIAP Homo sapiens P98170
Confocal
31260151
种属内
HTRA3 P83110 HTRA3 Homo sapiens P83110
GMS
31899476
种属内
HTRA3 P83110 HTRA3 Homo sapiens P83110
X-Ray Diffraction
26110759
种属内
HTRA3 P83110 TCP1 Homo sapiens P17987
Anti Bait CoIP
29477555
种属间
HTRA3 P83110 CSN2 Bos taurus P02666
GMS
26110759
种属间
HTRA3 P83110 CSN2 Bos taurus P02666
Protease Assay
26110759
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06488 HTRA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HTRA3 MGD MGI:1925808
Felis catus HTRA3 VGNC VGNC:62856
Bos taurus HTRA3 VGNC VGNC:59337
Canis familiaris HTRA3 VGNC VGNC:41837
Rattus norvegicus HTRA3 RGD RGD:1308120
Macaca mulatta HTRA3 VGNC VGNC:82160
Others HTRA3 NCBI
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