HTRA4 - HtrA serine peptidase 4 Gene

中文名称：HtrA 丝氨酸肽酶 4

种属: Homo sapiens

关于 HTRA4

功能概要

该基因编码 HtrA 蛋白酶家族的一个成员。编码的蛋白质包含推定的信号肽、胰岛素生长因子结合结构域、Kazal 蛋白酶抑制剂结构域、保守的胰蛋白酶结构域和 PDZ 结构域。基于对其他相关家族成员的研究，该酶可能作为分泌型寡聚伴侣蛋白酶来降解错误折叠的分泌蛋白。其他人类 HtrA 蛋白与关节炎、肿瘤抑制、未折叠应激反应、细胞凋亡和衰老有关。[RefSeq 提供，2008 年 10 月]

This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an Insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on Other related family members, this Enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, Apoptosis, and aging. [provided by RefSeq, Oct 2008]