2. Gene
  3. CDC42EP3 - CDC42 effector protein 3 Gene

CDC42EP3 - CDC42 effector protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CDC42 效应蛋白 3

种属: Homo sapiens

同用名: UB1; CEP3; BORG2

基因 ID: 10602 | 基因类型: protein coding

关于 CDC42EP3

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,641,944-37,672,949 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues and 5 paralogues. Broad expression in prostate (RPKM 28.7), endometrium (RPKM 27.8) and 23 other tissues.

功能概要

该基因编码一个包含 CRIB (Cdc42，Rac 相互作用结合) 结构域的三磷酸鸟苷 (GTP) 代谢蛋白小家族的成员。该蛋白质家族的成员充当 CDC42 功能的效应子。编码的蛋白质参与细胞形状变化期间肌动蛋白细胞骨架的重组，包括伪足形成。在 19 号染色体上发现了该基因的假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin Cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

CDC42EP3 基因产物(6)

mRNA Protein Name
NM_001270436.2 NP_001257365.1 cdc42 effector protein 3
NM_001270437.2 NP_001257366.1 cdc42 effector protein 3
NM_001270438.2 NP_001257367.1 cdc42 effector protein 3
NM_001371569.1 NP_001358498.1 cdc42 effector protein 3
NM_001371570.1 NP_001358499.1 cdc42 effector protein 3
NM_006449.5 NP_006440.2 cdc42 effector protein 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24947832 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CDC42EP3 蛋白结构

PBD

PBD: P21-Rho-binding domain (30 - 81)

BORG_CEP

BORG_CEP: Cdc42 effector (102 - 253)

  • 0
  • 100
  • 200
  • 254 a.a.
蛋白主名 其他名称

cdc42 effector protein 3

CDC42 effector protein (Rho GTPase binding) 3

CDC42EP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC42EP3 Q9UKI2 LRRK2 Homo sapiens Q5S007
Protein Array
24947832
种属内
CDC42EP3 Q9UKI2 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency

Vertebrobasilar Arterial Insufficiency

Vertebrobasilar Artery Syndrome
Retinitis Pigmentosa 11

RP11

Retinitis Pigmentosa-11

Retinitis Pigmentosa, Type 11
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02304 CDC42EP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CDC42EP3 VGNC VGNC:39002
Rattus norvegicus CDC42EP3 RGD RGD:1305858
Macaca mulatta CDC42EP3 VGNC VGNC:70777
Mus musculus CDC42EP3 MGD MGI:2384718
Bos taurus CDC42EP3 VGNC VGNC:27074
Felis catus CDC42EP3 VGNC VGNC:60661
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