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  2. SH2B2 - SH2B adaptor protein 2 Gene

SH2B2 - SH2B adaptor protein 2 Gene

中文名称:SH2B 衔接蛋白 2

种属: Homo sapiens

同用名: APS

基因 ID: 10603 | 基因类型: protein coding

关于 SH2B2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:102,285,141-102,321,711 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 2.3), spleen (RPKM 2.2) and 22 other tissues.

功能概要

该基因编码的蛋白质在 B 淋巴细胞中表达,包含 pleckstrin 同源性和 Src 同源性 2 (SH2) 结构域。在 Burkitt 淋巴瘤细胞系中,它响应于 B 细胞受体刺激而被酪氨酸磷酸化。因为它与刺激无关的 Shc 和刺激后的 Grb2 结合,所以它似乎在从受体到 Shc/Grb2 通路的信号转导中发挥作用。[RefSeq 提供,2009 年 6 月]

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and Src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]

SH2B2 基因产物(11)

mRNA Protein Name
NM_001359228.2 NP_001346157.1 SH2B adapter protein 2 isoform 2
NM_001359229.2 NP_001346158.1 SH2B adapter protein 2 isoform 2
NM_001359230.2 NP_001346159.1 SH2B adapter protein 2 isoform 3
NM_001359231.2 NP_001346160.1 SH2B adapter protein 2 isoform 3
NM_001393990.3 NP_001380919.2 SH2B adapter protein 2 isoform 3
NM_001393991.3 NP_001380920.2 SH2B adapter protein 2 isoform 2
NM_001393992.3 NP_001380921.2 SH2B adapter protein 2 isoform 3
NM_001393993.1 NP_001380922.1 SH2B adapter protein 2 isoform 2
NM_001393994.1 NP_001380923.1 SH2B adapter protein 2 isoform 2
NM_001393995.1 NP_001380924.1 SH2B adapter protein 2 isoform 7
NM_001394426.1 NP_001381355.1 SH2B adapter protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH2 domain binding IDA
IDA: 通过直接分析推断
9233773 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15737992 GOA
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
9233773 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
9233773 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9989826 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9989826 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SH2B2 蛋白结构

Phe_ZIP

Phe_ZIP: Phenylalanine zipper (64 - 122)

PH

PH: PH domain (238 - 347)

SH2

SH2: SH2 domain (454 - 533)

  • 0
  • 200
  • 400
  • 600
  • 671 a.a.
蛋白主名 其他名称

SH2B adapter protein 2

SH2 and PH domain-containing adapter protein APS

SH2B2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH2B2 O14492 CBL Homo sapiens P22681
ITC
18273061
种属内
SH2B2 O14492 CBL Homo sapiens P22681
Anti Tag CoIP
18273061
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Erythrocytosis, Familial, 7

ECYT7

Erythrocytosis 7

Familial Erythrocytosis 7

Erythrocytosis, Alpha-Globin Type

Polycythemia, Alpha-Globin Type

Alpha-Globin Type Erythrocytosis

Alpha-Globin Type Polycythemia

Erythrocytosis, Familial, 6

ECYT6

Erythrocytosis 6

Familial Erythrocytosis 6

Erythrocytosis, Beta-Globin Type

Polycythemia, Beta-Globin Type

Beta-Globin Type Erythrocytosis

Beta-Globin Type Polycythemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SH2B2 MGD MGI:1345171
Bos taurus SH2B2 VGNC VGNC:59364
Felis catus SH2B2 VGNC VGNC:65089
Rattus norvegicus SH2B2 RGD RGD:69284
Macaca mulatta SH2B2 VGNC VGNC:77257