TAF6L - TATA-box binding protein associated factor 6 like Gene

中文名称：TATA 盒结合蛋白相关因子 6 样

种属: Homo sapiens

同用名: PAF65A

关于 TAF6L

功能概要

RNA 聚合酶 II 启动转录需要 70 多种多肽的活性。协调这些活动的蛋白质是转录因子 IID (TFIID) ，它与核心启动子结合以正确定位聚合酶，充当组装转录复合物其余部分的支架，并充当调节信号的通道。 TFIID 由 TATA 结合蛋白 (TBP) 和一组称为 TBP 相关因子或 TAF 的进化保守蛋白组成。 TAF 可能参与基础转录，充当共激活因子，在启动子识别中发挥作用或修饰一般转录因子 (GTF) 以促进复杂的组装和转录起始。该基因编码的蛋白质是 PCAF 组蛋白乙酰化酶复合物的一个组成部分，在结构上类似于一种组蛋白样 TAF，TAF6。 PCAF 组蛋白乙酰化酶复合物由 20 多种多肽组成，其中一些是 TAF，是肌源性转录和分化所必需的。[RefSeq 提供，2008 年 7 月]

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]