FUT9 - fucosyltransferase 9 Gene

中文名称：岩藻糖基转移酶 9

种属: Homo sapiens

同用名: Fuc-TIX

基因 ID: 10690 | 基因类型: protein coding

关于 FUT9

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:96,015,974-96,215,612 (from NCBI)

This gene has 2 transcripts (splice variants), 480 orthologues and 7 paralogues. Biased expression in brain (RPKM 9.0), stomach (RPKM 7.9) and 2 other tissues.

功能概要

该基因编码的蛋白质属于糖基转移酶家族。它定位于高尔基体，并催化 Lewis X (LeX) 抗原生物合成的最后一步，即向前体多糖添加岩藻糖。这种蛋白质是合成 LeX 寡糖 (CD15) 的少数岩藻糖基转移酶之一，该酶在胚胎发生过程中在间充质中进展的器官芽中表达。它还负责 CD15 在成熟粒细胞中的表达。该基因的一个常见单倍型也与胎盘疟疾感染的易感性有关。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene belongs to the Glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor Polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria Infection. [provided by RefSeq, Nov 2011]

FUT9 基因产物(1)

mRNA	Protein	Name
NM_006581.4	NP_006572.2	4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IDA IDA: 通过直接分析推断	11278338	GOA
enables 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity	IMP IMP: 通过突变表型推断	10622713	GOA
enables alpha-(1->3)-fucosyltransferase activity	IDA IDA: 通过直接分析推断	37202521	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	37202521	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Lewis x epitope biosynthetic process	IDA IDA: 通过直接分析推断	29593094	GOA
involved in fucosylation	IDA IDA: 通过直接分析推断	18395013	GOA
involved in glycosphingolipid biosynthetic process	IDA IDA: 通过直接分析推断	29593094	GOA
involved in neuron differentiation	IDA IDA: 通过直接分析推断	17335083	GOA
involved in positive regulation of neuron projection development	IMP IMP: 通过突变表型推断	23000574	GOA
involved in protein N-linked glycosylation	IDA IDA: 通过直接分析推断	29593094	GOA
involved in protein O-linked glycosylation	IDA IDA: 通过直接分析推断	29593094	GOA
involved in regulation of leukocyte cell-cell adhesion	IMP IMP: 通过突变表型推断	23192350	GOA
involved in regulation of leukocyte tethering or rolling	IMP IMP: 通过突变表型推断	23192350	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in trans-Golgi network	IDA IDA: 通过直接分析推断	23192350	GOA
located in trans-Golgi network membrane	IDA IDA: 通过直接分析推断	18395013	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FUT9 蛋白结构

Glyco_transf_10

0
100
200
300
359 a.a.

蛋白主名

其他名称

4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9

alpha-(1,3)-fucosyltransferase 9

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 46

MRD46	Mental Retardation, Autosomal Dominant 46
Autosomal Dominant Mental Retardation 46	Autosomal Dominant Intellectual Developmental Disorder 46
Mental Retardation, Autosomal Dominant, Type 46

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05160	FUT9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	FUT9	VGNC	VGNC:72830
Felis catus	FUT9	VGNC	VGNC:62395
Mus musculus	FUT9	MGD	MGI:1330859
Bos taurus	FUT9	VGNC	VGNC:29153
Rattus norvegicus	FUT9	RGD	RGD:619955
Canis familiaris	FUT9	VGNC	VGNC:41016

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FUT9 - fucosyltransferase 9 Gene

关于 FUT9

功能概要

FUT9 基因产物(1)

FUT9 蛋白结构

关联疾病

直系同源

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FUT9 - fucosyltransferase 9 Gene

关于 FUT9

功能概要

FUT9 基因产物(1)

FUT9 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z