CORIN - corin, serine peptidase Gene

中文名称：corin, 丝氨酸肽酶

种属: Homo sapiens

同用名: CRN; ATC2; Lrp4; PEE5; TMPRSS10

基因 ID: 10699 | 基因类型: protein coding

关于 CORIN

Cytogenetic location: 4p12 Genomic coordinates (GRCh38): 4:47,594,001-47,838,067 (from NCBI)

This gene has 11 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Biased expression in heart (RPKM 20.5), skin (RPKM 3.4) and 2 other tissues.

功能概要

该基因编码胰蛋白酶超家族的 II 型跨膜丝氨酸蛋白酶类成员。这个家族的成员由多个结构不同的域组成。编码的蛋白质将促心房利钠肽转化为具有生物活性的心房利钠肽，这是一种调节血容量和压力的心脏激素。该蛋白质还可以作为前脑型利尿钠肽转化酶发挥作用。已为该基因发现编码不同亚型的多个可变剪接转录物变体。[RefSeq 提供，2013 年 6 月]

This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

CORIN 基因产物(3)

mRNA	Protein	Name
NM_001278585.2	NP_001265514.1	atrial natriuretic peptide-converting enzyme isoform 2
NM_001278586.2	NP_001265515.1	atrial natriuretic peptide-converting enzyme isoform 3
NM_006587.4	NP_006578.2	atrial natriuretic peptide-converting enzyme isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables endopeptidase activity	IMP IMP: 通过突变表型推断	20489134	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables serine-type endopeptidase activity	IDA IDA: 通过直接分析推断	10880574	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in female pregnancy	IMP IMP: 通过突变表型推断	22437503	GOA
involved in peptide hormone processing	IDA IDA: 通过直接分析推断	10880574	GOA
involved in regulation of systemic arterial blood pressure by atrial natriuretic peptide	IMP IMP: 通过突变表型推断	22437503	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	21518754	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CORIN 蛋白结构

Ldl_recept_a

SRCR_2

Trypsin

0
200
400
600
800
1042 a.a.

蛋白主名

其他名称

atrial natriuretic peptide-converting enzyme

heart-specific serine proteinase ATC2

CORIN 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CORIN	Q9Y5Q5	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
种属内	CORIN	Q9Y5Q5	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
种属内	CORIN	Q9Y5Q5	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	CORIN	Q9Y5Q5	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	CORIN	Q9Y5Q5	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
种属内	CORIN	Q9Y5Q5	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
种属内	CORIN	Q9Y5Q5	EMP1	Homo sapiens	P54849	Y2H Array	32296183
种属内	CORIN	Q9Y5Q5	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Preeclampsia/Eclampsia 5

PEE5	Pre-Eclampsia/Eclampsia 5
Gestational Proteinuric Hypertension	Preeclampsia/Eclampsia, Type 5

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Cone-Rod Dystrophy 12

CORD12

Dystrophy, Cone-Rod, Type 12

St. Louis Encephalitis

Saint Louis Encephalitis	Neuroinvasive St. Louis Encephalitis Virus Infection
Encephalitis, St. Louis	Neuroinvasive Saint Louis Encephalitis Virus Infection
St. Louis Encephalitis Virus Infection	St. Louis Encephalitis Virus Neuroinvasive Disease
St. Louis Viral Disease	Type C Lethargic Encephalitis
Encephalitis Type C

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-111048	Corin	Inhibitor	98.55%	否
HY-RS03047	CORIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CORIN	VGNC	VGNC:27619
Felis catus	CORIN	VGNC	VGNC:78471
Macaca mulatta	CORIN	VGNC	VGNC:71212
Canis familiaris	CORIN	VGNC	VGNC:39526
Rattus norvegicus	CORIN	RGD	RGD:727887
Mus musculus	CORIN	MGD	MGI:1349451
Others	CORIN	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CORIN - corin, serine peptidase Gene

关于 CORIN

功能概要

CORIN 基因产物(3)

CORIN 蛋白结构

CORIN 蛋白互作信息

关联疾病

直系同源

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CORIN - corin, serine peptidase Gene

关于 CORIN

功能概要

CORIN 基因产物(3)

CORIN 蛋白结构

CORIN 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z