2. Gene
  3. Nod1 - nucleotide-binding oligomerization domain containing 1 Gene

Nod1 - nucleotide-binding oligomerization domain containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含核苷酸结合寡聚化结构域 1

种属: Mus musculus

同用名: Card4; Nlrc1; C230079P11; F830007N14Rik

基因 ID: 107607 | 基因类型: protein coding

关于 Nod1

Chromosome 6: 54,900,934-54,949,597 reverse strand.GRCm39:CM000999.3

This gene has 6 transcripts (splice variants), 201 orthologues, 22 paralogues and is associated with 6 phenotypes. Broad expression in lung adult (RPKM 28.6), spleen adult (RPKM 22.7) and 19 other tissues.

功能概要

预计该基因编码的蛋白可启动 CARD 域绑定活动；模式识别受体活动；和蛋白质同二聚化活性。参与树突状细胞抗原加工和呈递的正调控。作用于多个过程的上游或内部，包括细胞因子产生的正向调节；细胞内信号转导的正向调节；和异种吞噬的正调控。位于吞噬泡内。以多种结构表达，包括消化系统；脑;嗅觉上皮；泌尿系统;和触须。该基因的人类直系同源物与哮喘有关。与人 NOD1 同源（包含 1 的核苷酸结合寡聚化结构域）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable CARD domain binding activity; pattern recognition receptor activity; and protein homodimerization activity. Involved in positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; brain; olfactory epithelium; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Nod1 基因产物(4)

mRNA Protein Name
NM_172729.3 NP_766317.1 nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1 NP_001164478.1 nucleotide-binding oligomerization domain-containing protein 1
NM_001171007.1 NP_001164478.1 nucleotide-binding oligomerization domain-containing protein 1
NM_172729.3 NP_766317.1 nucleotide-binding oligomerization domain-containing protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables pattern recognition receptor activity IDA
IDA: 通过直接分析推断
18261938 MGI
enables peptidoglycan binding IDA
IDA: 通过直接分析推断
16211083 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19898471 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of JNK cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within defense response to Gram-positive bacterium IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of interleukin-6 production IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
18261938 MGI
involved in nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
IDA: 通过直接分析推断
27007849 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
18261938 MGI
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
19898471 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
18261938 MGI
involved in positive regulation of dendritic cell antigen processing and presentation IMP
IMP: 通过突变表型推断
20008287 MGI
acts upstream of or within positive regulation of interleukin-6 production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of or within positive regulation of stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of or within positive regulation of xenophagy IMP
IMP: 通过突变表型推断
22033934 MGI
involved in response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
27007849 MGI
acts upstream of stress-activated MAPK cascade IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of tumor necrosis factor production IGI
IGI: 通过遗传相互作用推断
18261938 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
18261938 MGI
acts upstream of xenophagy IMP
IMP: 通过突变表型推断
22033934 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
31649195 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nod1 蛋白结构

DD

DD: cl14633 (20 - 103)

NACHT

NACHT: pfam05729 (196 - 366)

NOD2_WH

NOD2_WH: pfam17779 (459 - 514)

NLRC4_HD2

NLRC4_HD2: cl39284 (516 - 664)

PPP1R42

PPP1R42: cl42388 (727 - 940)

LRR_RI

LRR_RI: sd00033 (729 - 756)

LRR_RI

LRR_RI: sd00033 (757 - 784)

LRR_RI

LRR_RI: sd00033 (785 - 812)

LRR_RI

LRR_RI: sd00033 (813 - 840)

LRR_RI

LRR_RI: sd00033 (841 - 868)

LRR_RI

LRR_RI: sd00033 (869 - 896)

LRR_RI

LRR_RI: sd00033 (897 - 924)

LRR_RI

LRR_RI: sd00033 (925 - 945)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 953 a.a.
蛋白主名 其他名称

nucleotide-binding oligomerization domain-containing protein 1

caspase recruitment domain 4

caspase recruitment domain-containing protein 4

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100691 NOD-IN-1 Inhibitor 99.56% 否
HY-168023 NOD1-IN-1 Inhibitor / 否
HY-146034 NOD1/2 antagonist-1 Antagonist / 否
HY-163274 NOD1 antagonist-1 Antagonist / 否
HY-168024 NOD1/2-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nod1 NCBI NCBI:10392
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