FRS2 - fibroblast growth factor receptor substrate 2 Gene

中文名称：成纤维细胞生长因子受体底物 2

种属: Homo sapiens

同用名: SNT; SNT1; FRS1A; FRS2A; SNT-1; FRS2alpha

基因 ID: 10818 | 基因类型: protein coding

关于 FRS2

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:69,470,388-69,579,793 (from NCBI)

This gene has 11 transcripts (splice variants), 230 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 6.6), endometrium (RPKM 6.6) and 25 other tissues.

功能概要

启用成纤维细胞生长因子受体结合活性和神经营养蛋白 TrkA 受体结合活性。参与心肌细胞分化的负调节。作用于成纤维细胞生长因子受体信号通路的上游或内部。位于 adherens 路口。肾细胞癌的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables Fibroblast Growth Factor receptor binding activity and neurotrophin TrkA receptor binding activity. Involved in negative regulation of cardiac muscle cell differentiation. Acts upstream of or within Fibroblast Growth Factor receptor signaling pathway. Located in adherens junction. Biomarker of renal cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

FRS2 基因产物(8)

mRNA	Protein	Name
NM_001042555.3	NP_001036020.1	fibroblast growth factor receptor substrate 2
NM_001278351.2	NP_001265280.1	fibroblast growth factor receptor substrate 2
NM_001278353.2	NP_001265282.1	fibroblast growth factor receptor substrate 2
NM_001278354.2	NP_001265283.1	fibroblast growth factor receptor substrate 2
NM_001278355.2	NP_001265284.1	fibroblast growth factor receptor substrate 2
NM_001278356.2	NP_001265285.1	fibroblast growth factor receptor substrate 2
NM_001278357.2	NP_001265286.1	fibroblast growth factor receptor substrate 2
NM_006654.5	NP_006645.3	fibroblast growth factor receptor substrate 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables fibroblast growth factor receptor binding	IPI IPI: 通过物理相互作用推断	9660748	GOA
enables neurotrophin TRKA receptor binding	IPI IPI: 通过物理相互作用推断	15488758	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9632781	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	9660748	GOA
involved in negative regulation of cardiac muscle cell differentiation	IGI IGI: 通过遗传相互作用推断	23939491	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in adherens junction	IDA IDA: 通过直接分析推断	25468996	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FRS2 蛋白结构

IRS

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

fibroblast growth factor receptor substrate 2

FGFR signalling adaptor

FRS2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FRS2	Q8WU20	FGFR1	Homo sapiens	P11362	Anti Tag CoIP	21765395
种属内	FRS2	Q8WU20	PTPN11	Homo sapiens	Q06124	CoIP	9632781

种属间: 跨种属相互作用 种属内: 同种属相互作用

FRS2 抗体

目录号	产品名	应用	反应物种
HY-P81655	FRS2 Antibody (YA1400)	WB, IP	Human

关联疾病

疾病名称

别名

Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans

SADDAN	Saddan Dysplasia
Severe Achondroplasia With Developmental Delay And Acanthosis Nigricans	Severe Achondroplasia-Developmental Delay-Acanthosis Nigricans Syndrome
Ssb Syndrome	Skeleton Skin Brain Syndrome
Skeleton-Skin-Brain Syndrome	Achondroplasia

Liposarcoma

Lipomatous Cancer

Beare-Stevenson Cutis Gyrata Syndrome

Cutis Gyrata Syndrome Of Beare And Stevenson	Beare-Stevenson Syndrome
BSTVS	Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Beare Stevenson Syndrome	Cutis Gyrata - Acanthosis Nigricans - Craniosynostosis
Cutis Gyrata Syndrome Of Beare-Stevenson

Central Nervous System Lipoma

Lipoma Of The Cns

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Parosteal Osteosarcoma

Juxtacortical Osteosarcoma	Parosteal Osteogenic Sarcoma
Osteosarcoma, Juxtacortical

Thanatophoric Dysplasia, Type I

Thanatophoric Dysplasia	Thanatophoric Dwarfism
Thanatophoric Dysplasia Type 1	TD1
Td	Thanatophoric Short Stature
Thanatophoric Dwarfism Type 1	Thanatophoric Dysplasia Type I
Platyspondylic Lethal Skeletal Dysplasia, San Diego Type	Lethal Short-Limbed Platyspondylic Dwarfism, San Diego Type
Skeletal Dysplasia, San Diego Type	Plsd San Diego Type
Thanatophoric Dwarfism 1	Dwarfism Thanatophoric
Dwarf, Thanatophoric	Thanatophoric Dysplasia 1
Lethal Short-Limbed Platyspondylic Dwarfism San Diego Type	Platyspondylic Lethal Skeletal Dysplasia San Diego Type
Thanatophoric Dwarf	Thanatophoric Dwarfism Or Short Stature
Thanatophoric Dwarfism Syndrome	Td - [Thanatophoric Dwarfism]

Peripheral Osteosarcoma

Surface Osteosarcoma

Bone Surface Osteosarcoma

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor	Atypical Lipoma
Alt	Wdls
Liposarcoma, Well Differentiated	Pleomorphic Lipoma

Crouzon Syndrome

Crouzon Craniofacial Dysostosis	Craniofacial Dysostosis
Cfd1	Craniofacial Dysostosis Type 1
Crouzon Disease	Crouzon'S Disease
Craniofacial Dysostosis, Type I	Craniofacial Dysarthrosis
Craniofacial Dysostosis Syndrome	CS
Craniofacial Dysostosis Type I	Vogt Cephalosyndactyly

Pleomorphic Liposarcoma

Pls	Liposarcoma Pleomorphic
Liposarcoma, Pleomorphic

Dedifferentiated Liposarcoma

Ddls	Liposarcoma Dedifferentiated
Liposarcoma, Dedifferentiated

Lacrimoauriculodentodigital Syndrome

Ladd Syndrome	Levy-Hollister Syndrome
Lacrimo-Auriculo-Dento-Digital Syndrome	LADD
Lacrimoauriculodento-Digital Syndrome	Levy Hollister Syndrome
Lard Syndrome	Lacrimoauriculoradiodental Syndrome
LADDS	Congenital Duodenal Obstruction Due To Malrotation Of Intestine

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-158248	FGFR4-IN-19	Inhibitor	/	否
HY-RS05112	FRS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FRS2	RGD	RGD:1308201
Felis catus	FRS2	VGNC	VGNC:84021
Mus musculus	FRS2	MGD	MGI:1100860
Bos taurus	FRS2	VGNC	VGNC:29120
Macaca mulatta	FRS2	VGNC	VGNC:72732
Canis familiaris	FRS2	VGNC	VGNC:40986

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FRS2 - fibroblast growth factor receptor substrate 2 Gene

关于 FRS2

功能概要

FRS2 基因产物(8)

FRS2 蛋白结构

FRS2 蛋白互作信息

FRS2 抗体

关联疾病

直系同源

热门区域

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FRS2 - fibroblast growth factor receptor substrate 2 Gene

关于 FRS2

功能概要

FRS2 基因产物(8)

FRS2 蛋白结构

FRS2 蛋白互作信息

FRS2 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z