2. Gene
  3. PDE10A - phosphodiesterase 10A Gene

PDE10A - phosphodiesterase 10A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 10A

种属: Homo sapiens

同用名: ADSD2; IOLOD; HSPDE10A; PDE10A19; LINC00473

基因 ID: 10846 | 基因类型: protein coding

关于 PDE10A

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:165,327,289-165,988,052 (from NCBI)

This gene has 40 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 5 phenotypes.

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶家族。它通过调节细胞内环核苷酸的浓度在信号转导中发挥作用。该蛋白可将 cAMP 和 cGMP 均水解为相应的核苷 5'一磷酸，但对 cAMP 具有更高的亲和力，以 cAMP 为底物时效率更高。已经描述了该基因的可变剪接转录物变体。[RefSeq 提供，2011 年 12 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]

PDE10A 基因产物(14)

mRNA Protein Name
XM_011535388.4 XP_011533690.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_017010194.3 XP_016865683.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2
NM_006661.4 NP_006652.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_001385079.1 NP_001372008.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3
XM_047418099.1 XP_047274055.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
NM_001130690.3 NP_001124162.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
XM_006715321.5 XP_006715384.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X4
XM_017010195.3 XP_016865684.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418101.1 XP_047274057.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6
NR_045597.1
XM_047418100.1 XP_047274056.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5
XM_047418098.1 XP_047274054.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3
XM_011535387.4 XP_011533689.2 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1
XM_017010197.3 XP_016865686.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X7

PDE10A 蛋白结构

GAF

GAF: GAF domain (142 - 233)

GAF

GAF: GAF domain (268 - 412)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (514 - 748)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
蛋白主名 其他名称

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

3',5' cAMP/cGMP phosphodiesterase

dJ416F21.1 (phosphodiesterase 10A)

phosphodiesterase 10A1 (PDE10A1)

phosphodiesterase 10A7 (PDE10A7)

关联疾病

疾病名称 别名
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Striatal Degeneration, Autosomal Dominant 2

ADSD2

Striatal Degeneration, Autosomal Dominant

Childhood-Onset Benign Chorea With Striatal Involvement

Degeneration, Striatal, Autosomal Dominant, Type 2

Hyperactive Behavior
Dyskinesia, Limb And Orofacial, Infantile-Onset

IOLOD

Infantile-Onset Generalized Dyskinesia With Orofacial Involvement

Infantile-Onset Orofacial-Trunk-Limbs Dyskinesia
Choreatic Disease

Chorea

Hereditary Chorea
Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event
Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Neurodevelopmental Disorder With Involuntary Movements

NEDIM
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
生物活性分子 (22)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50098 Mardepodect Inhibitor 99.04% 否
HY-153093 MK-8189 Inhibitor 99.88% 否
HY-14550 TP-10 Inhibitor 99.88% 否
HY-117604 THPP-1 Inhibitor 98.75% 否
HY-18078 PQ-10 Inhibitor 99.77% 否
HY-12913 AMG 579 Inhibitor 99.02% 否
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% 否
HY-135848 N-Methylbenzamide Inhibitor 99.93% 否
HY-10568 TC-E 5005 Inhibitor / 否
HY-123743 JNJ-42314415 Inhibitor / 否
HY-152838 Gemlapodect Inhibitor / 否
HY-158237 PDE10A-IN-3 Inhibitor / 否
HY-160111 PDM-042 Inhibitor / 否
HY-161663 Phosphodiesterase-IN-2 Inhibitor / 否
HY-18037 AMG-7980 / 否
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-10030 Mardepodect succinate / 否
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / 否
HY-123154 PDE10A-IN-4 / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDE10A VGNC VGNC:68751
Mus musculus PDE10A MGD MGI:1345143
Rattus norvegicus PDE10A RGD RGD:68434
Bos taurus PDE10A VGNC VGNC:32668
Canis familiaris PDE10A VGNC VGNC:44345
Macaca mulatta PDE10A VGNC VGNC:75908
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z