2. Gene
  3. LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

LILRB1 - leukocyte immunoglobulin like receptor B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞免疫球蛋白样受体 B1

种属: Homo sapiens

同用名: ILT2; LIR1; MIR7; PIRB; CD85J; ILT-2; LIR-1; MIR-7; PIR-B

基因 ID: 10859 | 基因类型: protein coding

关于 LILRB1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,616,322-54,638,022 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 304 orthologues and 25 paralogues. Biased expression in appendix (RPKM 25.9), spleen (RPKM 20.5) and 10 other tissues.

功能概要

该基因是白细胞免疫球蛋白样受体 (LIR) 家族的成员，该家族位于染色体区域 19q13.4 的基因簇中。编码的蛋白质属于 B 类 LIR 受体亚科，其中包含两个或四个细胞外免疫球蛋白结构域、一个跨膜结构域和两个至四个基于细胞质免疫受体酪氨酸的抑制基序 (ITIM) 。该受体在免疫细胞上表达，在那里它与抗原呈递细胞上的 MHC I 类分子结合，并转导抑制免疫反应刺激的负信号。它被认为可以控制炎症反应和细胞毒性，以帮助集中免疫反应并限制自身反应性。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LILRB1 基因产物(10)

mRNA Protein Name
NM_001081637.3 NP_001075106.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_001081638.4 NP_001075107.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001081639.4 NP_001075108.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001278398.2 NP_001265327.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor
NM_001278399.2 NP_001265328.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor
NM_001388355.1 NP_001375284.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388356.1 NP_001375285.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor
NM_001388357.1 NP_001375286.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor
NM_001388358.1 NP_001375287.1 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor
NM_006669.7 NP_006660.4 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables HLA-A specific inhibitory MHC class I receptor activity IDA
IDA: 通过直接分析推断
18684926 GOA
enables HLA-B specific inhibitory MHC class I receptor activity IDA
IDA: 通过直接分析推断
11907092 GOA
enables MHC class I protein binding IDA
IDA: 通过直接分析推断
9842885 GOA
enables MHC class I protein binding IMP
IMP: 通过突变表型推断
18398485 GOA
enables MHC class I protein binding IPI
IPI: 通过物理相互作用推断
9285411 GOA
enables MHC class I receptor activity IDA
IDA: 通过直接分析推断
9285411 GOA
enables MHC class Ib protein binding IDA
IDA: 通过直接分析推断
11169396 GOA
enables MHC class Ib protein complex binding IDA
IDA: 通过直接分析推断
17056715 GOA
enables MHC class Ib receptor activity IDA
IDA: 通过直接分析推断
24453251 GOA
enables SH2 domain binding IDA
IDA: 通过直接分析推断
11907092 GOA
NOT enables amyloid-beta binding IDA
IDA: 通过直接分析推断
24052308 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11169396 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
21213105 GOA
enables protein phosphatase 1 binding IPI
IPI: 通过物理相互作用推断
9285411 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Fc receptor mediated inhibitory signaling pathway IDA
IDA: 通过直接分析推断
9842885 GOA
involved in T cell proliferation involved in immune response IDA
IDA: 通过直接分析推断
18094328 GOA
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
18094328 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
15585844 GOA
involved in dendritic cell differentiation IEP
IEP: 通过表达模式推断
18094328 GOA
involved in negative regulation of CD8-positive, alpha-beta T cell activation IDA
IDA: 通过直接分析推断
21213105 GOA
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
21213105 GOA
involved in negative regulation of T cell proliferation IDA
IDA: 通过直接分析推断
15585844 GOA
involved in negative regulation of alpha-beta T cell activation IDA
IDA: 通过直接分析推断
21213105 GOA
involved in negative regulation of calcium ion transport IDA
IDA: 通过直接分析推断
9842885 GOA
involved in negative regulation of cell cycle IDA
IDA: 通过直接分析推断
21551166 GOA
involved in negative regulation of cytokine production involved in immune response IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of dendritic cell apoptotic process IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of dendritic cell differentiation IMP
IMP: 通过突变表型推断
18684926 GOA
involved in negative regulation of endocytosis IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of interferon-beta production IDA
IDA: 通过直接分析推断
21213105 GOA
involved in negative regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of mononuclear cell proliferation IDA
IDA: 通过直接分析推断
21551166 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
12874224 GOA
involved in negative regulation of osteoclast development IDA
IDA: 通过直接分析推断
18802077 GOA
involved in negative regulation of serotonin secretion IDA
IDA: 通过直接分析推断
11907092 GOA
involved in negative regulation of transforming growth factor beta production IDA
IDA: 通过直接分析推断
18094328 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
18684926 GOA
involved in negative regulation of type II interferon production IDA
IDA: 通过直接分析推断
17869268 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21551166 GOA
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
18398485 GOA
involved in positive regulation of gamma-delta T cell activation involved in immune response IDA
IDA: 通过直接分析推断
21233315 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
18094328 GOA
involved in positive regulation of macrophage cytokine production IDA
IDA: 通过直接分析推断
19304799 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
11907092 GOA
involved in response to virus IDA
IDA: 通过直接分析推断
9285411 GOA
involved in signal transduction IDA
IDA: 通过直接分析推断
18802077 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15585844 GOA
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
9285411 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LILRB1 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (64 - 154)

Ig_3

Ig_3: Immunoglobulin domain (160 - 235)

Ig_2

Ig_2: Immunoglobulin domain (261 - 353)

Ig_3

Ig_3: Immunoglobulin domain (363 - 436)

  • 0
  • 200
  • 400
  • 600
  • 701 a.a.
蛋白主名 其他名称

leukocyte immunoglobulin-like receptor subfamily B member 1

CD85 antigen-like family member J

LILRB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LILRB1 Q8NHL6 HLA-G Homo sapiens P17693
SPR
16455647
种属内
LILRB1 Q8NHL6 PTPN6 Homo sapiens P29350
Anti Bait CoIP
18802077
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LILRB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70179 LILRB1/CD85j/ILT2 Protein, Human (435a.a, HEK293, His) ADJ55949.1 (G24-H458) ≥95%
HY-P77980 LILRB1/CD85j/ILT2 Protein (Domain1&2), Human (HEK293, His) Q8NHL6-1 (G24-G221) ≥95%
HY-P77981 LILRB1/CD85j/ILT2 Protein, Human (346a.a, HEK293, His) Q8NHL6-1 (L116-V461) ≥95%
HY-P77982 LILRB1/CD85j/ILT2 Protein, Human (HEK293, mFc) Q8NHL6-1 (G24-H458) ≥95%
HY-P77985 LILRB1/CD85j/ILT2 Protein, Human (HEK293, His-Avi) Q8NHL6-1 (G24-H458) ≥95%

关联疾病

疾病名称 别名
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07651 LILRB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus LILRB1 MGD MGI:894311
Macaca fascicularis LILRB1 NCBI
Macaca mulatta LILRB1 NCBI NCBI:692340
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