RAB32 - RAB32, member RAS oncogene family Gene

中文名称：RAB32，RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 10981 | 基因类型: protein coding

关于 RAB32

Cytogenetic location: 6q24.3 Genomic coordinates (GRCh38): 6:146,543,833-146,554,953 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues and 68 paralogues. Broad expression in bone marrow (RPKM 49.7), spleen (RPKM 19.8) and 23 other tissues.

功能概要

由该基因编码的蛋白质将蛋白激酶 A 的 II 型调节亚基锚定到线粒体上，并有助于线粒体分裂。编码的蛋白质似乎也参与自噬和黑素体分泌。该基因的变异可能与麻风病有关。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in Autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]

RAB32 基因产物(1)

mRNA	Protein	Name
NM_006834.5	NP_006825.1	ras-related protein Rab-32

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables AP-1 adaptor complex binding	IPI IPI: 通过物理相互作用推断	22511774	GOA
NOT enables AP-2 adaptor complex binding	IDA IDA: 通过直接分析推断	22511774	GOA
enables AP-3 adaptor complex binding	IPI IPI: 通过物理相互作用推断	22511774	GOA
enables BLOC-2 complex binding	IPI IPI: 通过物理相互作用推断	22511774	GOA
enables GTP-dependent protein binding	IPI IPI: 通过物理相互作用推断	22511774	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	21808068	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21808068	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antigen processing and presentation	IMP IMP: 通过突变表型推断	19717423	GOA
involved in endosome to melanosome transport	IMP IMP: 通过突变表型推断	22511774	GOA
involved in melanosome assembly	IDA IDA: 通过直接分析推断	23084991	GOA
involved in melanosome assembly	IMP IMP: 通过突变表型推断	22511774	GOA
involved in mitochondrion organization	IMP IMP: 通过突变表型推断	25767741	GOA
involved in phagosome maturation	IMP IMP: 通过突变表型推断	21255211	GOA
involved in protein localization to membrane	IMP IMP: 通过突变表型推断	25767741	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in early endosome	IDA IDA: 通过直接分析推断	22511774	GOA
NOT located in early endosome lumen	IDA IDA: 通过直接分析推断	22511774	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	25767741	GOA
located in melanosome	IDA IDA: 通过直接分析推断	22511774	GOA
located in melanosome membrane	IDA IDA: 通过直接分析推断	23084991	GOA
located in membrane	IDA IDA: 通过直接分析推断	22511774	GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: 通过直接分析推断	25767741	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	23084991	GOA
located in mitochondrion	IDA IDA: 通过直接分析推断	25767741	GOA
located in phagocytic vesicle	IDA IDA: 通过直接分析推断	21255211	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAB32 蛋白结构

Ras

0
100
200
225 a.a.

蛋白主名

其他名称

ras-related protein Rab-32

RAB32 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RAB32	Q13637	LRMDA	Homo sapiens	A0A087WWI0	Y2H Prey Pooling	32296183
种属内	RAB32	Q13637	LRMDA	Homo sapiens	A0A087WWI0	Y2H Array	32296183
种属内	RAB32	Q13637	LRRK2	Homo sapiens	Q5S007	Anti Bait CoIP	25360523
种属内	RAB32	Q13637	LRRK2	Homo sapiens	Q5S007	FPS	31552791
种属内	RAB32	Q13637	LRRK2	Homo sapiens	Q5S007	Pull Down	31552791
种属内	RAB32	Q13637	LRRK2	Homo sapiens	Q5S007	Y2H	25360523
种属内	RAB32	Q13637	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	RAB32	Q13637	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	RAB32	Q13637	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Carpenter Syndrome 1

Carpenter Syndrome	Acrocephalopolysyndactyly Type Ii
Acps Ii	CRPT1
Acrocephalopolysyndactyly Type 2	Acrocephalosyndactyly, Type Ii
Acrocephalopolysyndactyly 2	Acps2
Acps 2	Type Ii Acrocephalosyndactyly
Carpenter Syndrome, Type 1	Apert-Crouzon Disease

Warburg Micro Syndrome 1

Warburg Micro Syndrome	Micro Syndrome
Warbm	WARBM1
Warburg Sjo Fledelius Syndrome	Warburg-Sjo-Fledelius Syndrome
Micro Syndrome 1	Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11545	RAB32 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	RAB32	MGD	MGI:1915094
Rattus norvegicus	RAB32	RGD	RGD:1559997
Canis familiaris	RAB32	VGNC	VGNC:53757
Bos taurus	RAB32	VGNC	VGNC:33641

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RAB32 - RAB32, member RAS oncogene family Gene

关于 RAB32

功能概要

RAB32 基因产物(1)

RAB32 蛋白结构

RAB32 蛋白互作信息

关联疾病

直系同源

热门区域

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RAB32 - RAB32, member RAS oncogene family Gene

关于 RAB32

功能概要

RAB32 基因产物(1)

RAB32 蛋白结构

RAB32 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z