1. Gene
  2. IL24 - interleukin 24 Gene

IL24 - interleukin 24 Gene

中文名称:白细胞介素 24

种属: Homo sapiens

同用名: C49A; FISP; MDA7; MOB5; ST16; IL10B

基因 ID: 11009 | 基因类型: protein coding

关于 IL24

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,897,443-206,904,139 (from NCBI)

This gene has 7 transcripts (splice variants), 158 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 12.3), spleen (RPKM 9.6) and 6 other tissues.

功能概要

该基因编码 IL10 细胞因子家族的成员。它被鉴定为在黑素瘤细胞终末分化过程中诱导的基因。该基因编码的蛋白质可以在多种癌细胞中选择性地诱导细胞凋亡。该基因的过度表达导致几个 GADD 家族基因的表达升高,这与细胞凋亡的诱导相关。丝裂原活化蛋白激酶 14 (MAPK7/P38) 和热休克 27kDa 蛋白 1 (HSPB2/HSP27) 的磷酸化被发现在黑素瘤细胞中由该基因诱导,但在正常的永生黑素细胞中不受此影响。已经报道了编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce Apoptosis selectively in various Cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of Apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

IL24 基因产物(4)

mRNA Protein Name
NM_001185156.1 NP_001172085.1 interleukin-24 isoform 3 precursor
NM_001185157.1 NP_001172086.1 interleukin-24 isoform 4 precursor
NM_001185158.1 NP_001172087.1 interleukin-24 isoform 5
NM_006850.3 NP_006841.1 interleukin-24 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25640309 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

interleukin-24

IL-4-induced secreted protein

IL24 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL24 Q13007 RAD51 Homo sapiens Q06609
Y2H Array
25640309
种属内
IL24 Q13007 RAD51 Homo sapiens Q06609
Anti Tag CoIP
25640309
种属内
IL24 Q13007 PARP1 Homo sapiens P09874
Y2H Array
25640309
种属内
IL24 Q13007 PARP1 Homo sapiens P09874
Anti Tag CoIP
25640309
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL24 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77003 IL-24 Protein, Human (HEK293, His) Q13007-2/NP_001172085.1 (Q53-L207) ≥95%
HY-P77004 IL-24 Protein, Human (HEK293, Fc) Q13007-2 (Q53-L207) ≥95%
HY-P700115AF Animal-Free IL-24 Protein, Human (His) Q13007-1 (Q52-L206) ≥95%

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Psoriasis
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Fungal Esophagitis
Chronic Inducible Urticaria
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Facial Hemiatrophy

Parry-Romberg Syndrome

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus IL24 VGNC VGNC:30148
Canis familiaris IL24 VGNC VGNC:41974
Rattus norvegicus IL24 RGD RGD:621484
Felis catus IL24 VGNC VGNC:107884
Mus musculus IL24 MGD MGI:2135548
Macaca mulatta IL24 VGNC VGNC:99981
Macaca fascicularis IL24 NCBI NCBI:102135102
Others IL24 NCBI