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  2. RAB35 - RAB35, member RAS oncogene family Gene

RAB35 - RAB35, member RAS oncogene family Gene

中文名称:RAB35,RAS 致癌基因家族成员

种属: Homo sapiens

同用名: RAY; H-ray; RAB1C

基因 ID: 11021 | 基因类型: protein coding

关于 RAB35

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,095,099-120,116,753 (from NCBI)

This gene has 6 transcripts (splice variants), 220 orthologues and 68 paralogues. Ubiquitous expression in spleen (RPKM 16.4), appendix (RPKM 14.7) and 25 other tissues.

功能概要

启用 GTPase 活动;胍基核糖核苷酸结合活性;和磷脂酰肌醇-4,5-二磷酸结合活性。参与多个过程,包括内体运输;质膜到核内体的运输;和蛋白质定位到核内体。位于几种细胞成分中,包括网格蛋白包被的内吞囊泡;网格蛋白涂层坑;和细胞间桥。 [由基因组资源联盟提供,2022 年 4 月]

Enables GTPase activity; guanyl ribonucleotide binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including endosomal transport; plasma membrane to endosome transport; and protein localization to endosome. Located in several cellular components, including clathrin-coated endocytic vesicle; clathrin-coated pit; and intercellular bridge. [provided by Alliance of Genome Resources, Apr 2022]

RAB35 基因产物(2)

mRNA Protein Name
NM_001167606.2 NP_001161078.1 ras-related protein Rab-35 isoform 2
NM_006861.7 NP_006852.1 ras-related protein Rab-35 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
17562788 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
16950109 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17562788 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation IMP
IMP: 通过突变表型推断
19717423 GOA
involved in endosomal transport IMP
IMP: 通过突变表型推断
16950109 GOA
involved in mitotic cytokinesis IMP
IMP: 通过突变表型推断
16950109 GOA
involved in plasma membrane to endosome transport IMP
IMP: 通过突变表型推断
17562788 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
16950109 GOA
involved in protein localization to endosome IMP
IMP: 通过突变表型推断
21951725 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell projection membrane IDA
IDA: 通过直接分析推断
16950109 GOA
located in clathrin-coated endocytic vesicle IDA
IDA: 通过直接分析推断
16950109 GOA
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
16950109 GOA
located in intercellular bridge IDA
IDA: 通过直接分析推断
16950109 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16950109 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAB35 蛋白结构

Ras

Ras: Ras family (10 - 168)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

ras-related protein Rab-35

GTP-binding protein RAY

RAB35 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB35 Q15286 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
RAB35 Q15286 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
RAB35 Q15286 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
RAB35 Q15286 MICALL1 Homo sapiens Q8N3F8
Y2H
21951725
种属内
RAB35 Q15286 MICALL1 Homo sapiens Q8N3F8
Anti Tag CoIP
21951725
种属内
RAB35 Q15286 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
种属内
RAB35 Q15286 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
种属内
RAB35 Q15286 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Familial Renal Oncocytoma
Lowe Oculocerebrorenal Syndrome

Lowe Syndrome

Oculocerebrorenal Syndrome

OCRL

Oculocerebrorenal Syndrome Of Lowe

Ocrl1

Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency

Lowe Disease

Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency

Cerebrooculorenal Syndrome

Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency

Lowe Oculo-Cerebro-Renal Dystrophy

Lowe Oculo-Cerebro-Renal Syndrome

Lowe Oculocerebrorenal Dystrophy

Low

Chromosome 11p Deletion Syndrome

Oculocerebrorenal Dystrophy

Cerebro-Oculorenal Dystrophy

Ocrl1 - [Oculocerebrorenal Syndrome]

Lowe-Terrey-Maclachlan Syndrome

Renal-Oculocerebrodystrophy

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome

Door Syndrome

Doors Syndrome

Digitorenocerebral Syndrome

Autosomal Recessive Deafness-Onychodystrophy Syndrome

Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome

DOORS

Drc Syndrome

Eronen Syndrome

Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Brachydactyly Due To Absence Of Distal Phalanges

Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome

Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome

Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome

Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome

Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome

Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome

Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome

Deafness, Congenital Onychodystrophy, Recessive Form

Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome

Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RAB35 RGD RGD:1306362
Felis catus RAB35 VGNC VGNC:107720
Canis familiaris RAB35 VGNC VGNC:45278
Bos taurus RAB35 VGNC VGNC:33644
Mus musculus RAB35 MGD MGI:1924657