Rps6ka3 - ribosomal protein S6 kinase polypeptide 3 Gene

中文名称：核糖体蛋白 S6 激酶多肽 3

种属: Mus musculus

同用名: Rsk2; MPK-9; p90RSK3; pp90RSK2; MAPKAPK-1b; S6K-alpha3

关于 Rps6ka3

功能概要

该基因编码的蛋白可启动蛋白激酶结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与对脂多糖和 toll 样受体信号通路的反应。预测位于胞质溶胶和核仁中。预计在细胞质和核质中有活性。以多种结构表达，包括消化系统；胚泡;鳃弓;中枢神经系统;和眼睛。用于研究 Coffin-Lowry 综合症。该基因的人类直系同源物与 Coffin-Lowry 综合征有关；智力残疾;和非综合征性 X 连锁智力障碍 19. 与人类 RPS6KA3（核糖体蛋白 S6 激酶 A3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in response to lipopolysaccharide and Toll-like Receptor signaling pathway. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in several structures, including alimentary system; blastocyst; branchial arch; central nervous system; and eye. Used to study Coffin-Lowry syndrome. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]