DNAJB4 - DnaJ heat shock protein family (Hsp40) member B4 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 B4

种属: Homo sapiens

同用名: DjB4; HLJ1; DNAJW

关于 DNAJB4

功能概要

由该基因编码的蛋白质是分子伴侣、肿瘤抑制因子和热休克蛋白 40 家族的成员。编码的蛋白质结合细胞粘附蛋白 E-钙粘蛋白并将其靶向质膜。这种蛋白质还结合错误折叠的 E-钙粘蛋白，并将其靶向内质网相关降解。该基因是结直肠癌的强抑癌基因，其下调可作为预测患者预后的良好生物标志物。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2015 年 11 月]

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]