2. Gene
  3. BTN3A1 - butyrophilin subfamily 3 member A1 Gene

BTN3A1 - butyrophilin subfamily 3 member A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嗜乳脂蛋白亚家族 3 成员 A1

种属: Homo sapiens

同用名: BTF5; BT3.1; CD277; BTN3.1

基因 ID: 11119 | 基因类型: protein coding

关于 BTN3A1

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,402,275-26,415,208 (from NCBI)

This gene has 11 transcripts (splice variants), 66 orthologues and 15 paralogues. Ubiquitous expression in spleen (RPKM 25.4), lymph node (RPKM 18.1) and 24 other tissues.

功能概要

嗜乳脂蛋白 (BTN) 基因是一组主要组织相容性复合体 (MHC) 相关基因，编码具有 2 个细胞外免疫球蛋白 (Ig) 结构域和细胞内 B30.2 (PRYSPRY) 结构域的 I 型膜蛋白。人类 BTN 基因的三个亚家族位于 MHC I 类区域：单拷贝 BTN1A1 基因 (MIM 601610) 和 BTN2 (例如，BTN2A1；MIM 613590) 和 BTN3 (例如，BNT3A1) 基因，它们经历了串联复制，每份各有 3 份 (Smith 等人总结，2010 [PubMed 20208008]) 。[OMIM 提供，2010 年 11 月]

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

BTN3A1 基因产物(4)

mRNA Protein Name
NM_001145008.2 NP_001138480.1 butyrophilin subfamily 3 member A1 isoform c precursor
NM_001145009.2 NP_001138481.1 butyrophilin subfamily 3 member A1 isoform d precursor
NM_007048.6 NP_008979.3 butyrophilin subfamily 3 member A1 isoform a precursor
NM_194441.3 NP_919423.1 butyrophilin subfamily 3 member A1 isoform b precursor

BTN3A1 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (31 - 134)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (164 - 226)

PRY

PRY: SPRY-associated domain (342 - 390)

SPRY

SPRY: SPRY domain (392 - 498)

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  • 513 a.a.
蛋白主名 其他名称

butyrophilin subfamily 3 member A1

dJ45P21.3 (butyrophilin, subfamily 3, member A1)

重组 BTN3A1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7683 BTN3A1/CD277 Protein, Human (HEK293, Fc) O00481-1 (Q30-G254) ≥95%
HY-P72763 BTN3A1/CD277 Protein, Human (HEK293, His) O00481-1 (Q30-G254) ≥95%
HY-P72345 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, Fc-Avi) O00481-1 (Q30-G254) ≥95%
HY-P76179 BTN3A1/CD277 Protein, Human (HEK293) O00481-1 (Q30-G254) ≥95%
HY-P76182 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His) O00481-1 (Q30-G254) ≥95%
HY-P78080 BTN3A1/CD277 Protein, Human (Biotinylated, HEK293, His-Avi) O00481-1 (Q30-G254) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01673 BTN3A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca fascicularis BTN3A1 NCBI
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