1. Gene
  2. STRAP - serine/threonine kinase receptor associated protein Gene

STRAP - serine/threonine kinase receptor associated protein Gene

中文名称:丝氨酸/苏氨酸激酶受体相关蛋白

种属: Homo sapiens

同用名: MAWD; PT-WD; UNRIP

基因 ID: 11171 | 基因类型: protein coding

关于 STRAP

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,882,387-15,903,478 (from NCBI)

This gene has 6 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in brain (RPKM 51.3), thyroid (RPKM 49.9) and 25 other tissues.

功能概要

启用 RNA 结合活性。参与维护胃肠上皮;转化生长因子β受体信号通路的负调控;和剪接体 snRNP 组装。位于胞质溶胶中。 SMN 复合体的一部分。与腺癌有关;结直肠癌;大细胞癌;肺癌;和鳞状细胞肿瘤。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Involved in maintenance of gastrointestinal epithelium; negative regulation of transforming growth factor beta receptor signaling pathway; and spliceosomal snRNP assembly. Located in cytosol. Part of SMN complex. Implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. [provided by Alliance of Genome Resources, Apr 2022]

STRAP 基因产物(1)

mRNA Protein Name
NM_007178.4 NP_009109.3 serine-threonine kinase receptor-associated protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15848170 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in maintenance of gastrointestinal epithelium IMP
IMP: 通过突变表型推断
17929853 GOA
acts upstream of positive effect negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
23687415 GOA
involved in spliceosomal snRNP assembly EXP
EXP: 通过实验结果推断
12067652 GOA
involved in spliceosomal snRNP assembly IDA
IDA: 通过直接分析推断
18984161 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SMN complex IDA
IDA: 通过直接分析推断
17178713 GOA
part of SMN complex IPI
IPI: 通过物理相互作用推断
17178713 GOA
part of SMN-Sm protein complex IDA
IDA: 通过直接分析推断
18984161 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17929853 GOA
located in cytosol IDA
IDA: 通过直接分析推断
18984161 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STRAP 蛋白结构

WD40

WD40: WD domain, G-beta repeat (9 - 39)

WD40

WD40: WD domain, G-beta repeat (53 - 87)

WD40

WD40: WD domain, G-beta repeat (98 - 128)

WD40

WD40: WD domain, G-beta repeat (138 - 170)

WD40

WD40: WD domain, G-beta repeat (256 - 292)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

serine-threonine kinase receptor-associated protein

MAP activator with WD repeats

STRAP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
26496610
Intra STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Pull Down
15848170
Intra STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
33961781
Intra STRAP Q9Y3F4 GEMIN7 Homo sapiens Q9H840
Anti Tag CoIP
28514442
Intra STRAP Q9Y3F4 NME1 Homo sapiens P15531
Confocal
17314099
Intra STRAP Q9Y3F4 NME1 Homo sapiens P15531
Y2H
17314099
Intra STRAP Q9Y3F4 NME1 Homo sapiens P15531
Anti Bait CoIP
17314099
Intra STRAP Q9Y3F4 NME1 Homo sapiens P15531
Comig Non-Denat Gel
17314099
Intra STRAP Q9Y3F4 GEMIN6 Homo sapiens Q8WXD5
Anti Tag CoIP
26496610
Intra STRAP Q9Y3F4 GEMIN6 Homo sapiens Q8WXD5
Pull Down
15848170
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 8, Autosomal Dominant

SPG8

Hereditary Spastic Paraplegia 8

Autosomal Dominant Spastic Paraplegia Type 8

Autosomal Dominant Spastic Paraplegia 8

Paraplegia, Spastic, Autosomal Dominant, Type 8

Childhood Spinal Muscular Atrophy

Spinal Muscular Atrophies Of Childhood

Survival Motor Neuron Spinal Muscular Atrophy

Large Cell Carcinoma

Carcinoma, Large Cell

Carcinoma Large Cell

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Spinal Muscular Atrophy, Type I

Werdnig-Hoffmann Disease

SMA1

Spinal Muscular Atrophy 1

Sma I

Sma, Infantile Acute Form

Muscular Atrophy, Infantile

Spinal Muscular Atrophy-1

Hmn Proximal Type I

Infantile Muscular Atrophy

Proximal Spinal Muscular Atrophy Type 1

Sma Type 1

Sma Type I

Sma-I

Hereditary Motor Neuropathy Proximal Type I

Progressive Muscular Atrophy Of Infancy

Proximal Spinal Muscular Atrophy, Type 1

Werdnig Hoffmann Disease

Infantile Spinal Muscular Atrophy

Infantile-Onset Spinal Muscular Atrophy

Proximal Hereditary Motor Neuropathy Type I

Sma Infantile Acute Form

Spinal Muscular Atrophy Type I

Werdnig-Hoffman Disease

Atrophy, Muscular, Spinal, Type 1

Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus STRAP MGD MGI:1329037
Macaca mulatta STRAP VGNC VGNC:100110
Rattus norvegicus STRAP RGD RGD:1311114
Bos taurus STRAP VGNC VGNC:35420
Canis familiaris STRAP VGNC VGNC:46941
Others STRAP NCBI