NISCH - nischarin Gene

中文名称：尼斯查林

种属: Homo sapiens

同用名: I-1; IR1; IRAS; hIRAS

基因 ID: 11188 | 基因类型: protein coding

关于 NISCH

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,455,604-52,493,068 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 30.5), prostate (RPKM 22.8) and 25 other tissues.

功能概要

该基因编码一种非肾上腺素能咪唑啉-1 受体蛋白，该蛋白定位于胞质溶胶并锚定于质膜的内层。直系同源小鼠蛋白已显示通过与 alpha-5-beta-1 整合素结合来影响细胞骨架组织和细胞迁移。在人类中，这种蛋白质已被证明与适配器胰岛素受体底物 4 (IRS4) 结合，以介导 alpha-5 整合素从细胞膜转移到核内体。该蛋白在人类乳腺癌中的表达减少，而其过度表达则减少了肿瘤的生长和转移；可能是通过限制 alpha-5 整合素的表达。在人类心脏组织中，该基因被发现影响细胞生长和死亡，而在神经组织中，它影响神经元的生长和分化。可变剪接导致编码不同亚型的多个转录变体。一些亚型缺乏功能性咪唑啉受体的预期 C 末端结构域。[RefSeq 提供，2013 年 1 月]

This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 Integrin. In humans, this protein has been shown to bind to the adapter Insulin Receptor substrate 4 (IRS4) to mediate translocation of alpha-5 Integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 Integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional Imidazoline Receptor. [provided by RefSeq, Jan 2013]

NISCH 基因产物(3)

mRNA	Protein	Name
NM_001276293.2	NP_001263222.2	nischarin isoform 2
NM_001276294.2	NP_001263223.2	nischarin isoform 3
NM_007184.4	NP_009115.3	nischarin isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	23386062	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23386062	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	15028622	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	15028622	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NISCH 蛋白结构

LRR_8

0
300
600
900
1200
1504 a.a.

蛋白主名

其他名称

nischarin

I-1 receptor candidate protein

NISCH 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NISCH	Q9Y2I1	RAB9A	Homo sapiens	P51151	Y2H	23386062
种属内	NISCH	Q9Y2I1	RAB9A	Homo sapiens	P51151	FRAP	23386062
种属内	NISCH	Q9Y2I1	RAB9A	Homo sapiens	P51151	Pull Down	23386062
种属内	NISCH	Q9Y2I1	RAB9A	Homo sapiens	P51151	IF	23386062
种属间	NISCH	Q9Y2I1	Rab14	Rattus norvegicus	P61107	IF	23386062
种属间	NISCH	Q9Y2I1	Rab14	Rattus norvegicus	P61107	Y2H	23386062
种属间	NISCH	Q9Y2I1	Rab14	Rattus norvegicus	P61107	FRAP	23386062
种属间	NISCH	Q9Y2I1	Rab4a	Rattus norvegicus	P05714	Y2H	23386062
种属间	NISCH	Q9Y2I1	Rab4a	Rattus norvegicus	P05714	FRAP	23386062
种属间	NISCH	Q9Y2I1	Rab14	Rattus norvegicus	P61107	CoIP	23386062

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Aplasia Of Lacrimal And Salivary Glands

ALSG	Congenital Absence Of Lacrimal Puncta And Salivary Glands
Xerostomia	Absence Of Salivary Glands
Parotid Aplasia Or Hypoplasia	Congenital Absence Of Lacrimal Puncta Or Salivary Glands
Alsg - [Aplasia Of Lacrimal Or Salivary Glands]

Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis	BRIC1
Summerskill Syndrome	Bric
Summerskill-Walshe-Tygstrup Syndrome	Cholestasis, Benign Recurrent Intrahepatic
Benign Recurrent Intrahepatic Cholestasis 1	Benign Recurrent Intrahepatic Cholestasis Type 1
Bric Type 1	Low Gamma-Gt Familial Intrahepatic Cholestasis
Recurrent Familial Intrahepatic Cholestasis	Cholestasis, Benign Recurrent Intrahepatic 1
Mild Atp8b1 Deficiency	Recurrent Familial Intrahepatic Cholestasis 1
Abcb11-Related Intrahepatic Cholestasis	Atp8b1-Related Intrahepatic Cholestasis
Cholestasis, Intrahepatic, Recurrent, Benign, Type 1	Progressive Intrahepatic Cholestasis
Cholestasis, Progressive Familial Intrahepatic 3	Bric - [Benign Recurrent Intrahepatic Cholestasis]

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Sclerosing Cholangitis

Fibrosing Cholangitis	Cholangitis, Sclerosing
Primary Sclerosing Cholangitis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09309	NISCH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NISCH	VGNC	VGNC:32088
Rattus norvegicus	NISCH	RGD	RGD:1306950
Felis catus	NISCH	VGNC	VGNC:80640
Mus musculus	NISCH	MGD	MGI:1928323
Canis familiaris	NISCH	VGNC	VGNC:43822
Macaca mulatta	NISCH	VGNC	VGNC:84147

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NISCH - nischarin Gene

关于 NISCH

功能概要

NISCH 基因产物(3)

NISCH 蛋白结构

NISCH 蛋白互作信息

关联疾病

直系同源

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NISCH - nischarin Gene

关于 NISCH

功能概要

NISCH 基因产物(3)

NISCH 蛋白结构

NISCH 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

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X

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