FDX2 - ferredoxin 2 Gene

中文名称：铁氧还蛋白 2

种属: Homo sapiens

同用名: FDX1L; MEOAL

基因 ID: 112812 | 基因类型: protein coding

关于 FDX2

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,310,045-10,316,015 (from NCBI)

This gene has 7 transcripts (splice variants), 180 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码铁氧还蛋白家族的一个成员。编码的蛋白质包含 2Fe-2S 铁氧还蛋白型结构域，对血红素 A 和 Fe/S 蛋白质生物合成至关重要。 FDX1L 基因的突变与线粒体肌肉肌病有关。[RefSeq 提供，2014 年 9 月]

This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]

FDX2 基因产物(1)

mRNA	Protein	Name
NM_001397406.1	NP_001384335.1	ferredoxin-2, mitochondrial

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables electron transfer activity	IDA IDA: 通过直接分析推断	28001042	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in [2Fe-2S] cluster assembly	IDA IDA: 通过直接分析推断	28001042	GOA
acts upstream of [4Fe-4S] cluster assembly	IDA IDA: 通过直接分析推断	28001042	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FDX2 蛋白结构

Fer2

0
100
183 a.a.

蛋白主名

其他名称

ferredoxin-2, mitochondrial

adrenodoxin-like protein, mitochondrial

FDX2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FDX2	Q6P4F2	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	FDX2	Q6P4F2	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	FDX2	Q6P4F2	LHX4	Homo sapiens	Q969G2	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mitochondrial Myopathy, Episodic, With Or Without Optic Atrophy And Reversible Leukoencephalopathy

Mitochondrial Myopathy, Episodic, With Optic Atrophy And Reversible Leukoencephalopathy	MEOAL
Mitochondrial Myopathy, Episodic, Without Optic Atrophy And Reversible Leukoencephalopathy

Mitochondrial Myopathy

Mitochondrial Myopathies	Mitochondrial Cytopathy
Myopathies In Mitochondrial Disorders

Combined Oxidative Phosphorylation Deficiency 19

COXPD19	Severe Neonatal Lactic Acidosis Due To Nfs1-Isd11 Complex Deficiency
Combined Oxidative Phosphorylation Deficiency, Type 19

Myopathy

Muscular Diseases

Myopathies

Nephrotic Syndrome, Type 9

NPHS9	Nephrotic Syndrome Type 9
Nephrotic Syndrome 9

Multiple Mitochondrial Dysfunctions Syndrome 1

MMDS1	Mmds
Nfu1 Deficiency	Multiple Mitochondrial Dysfunctions Syndrome Type 1
Mitochondrial Dysfunctions Syndrome, Multiple, Type 1

Multiple Mitochondrial Dysfunctions Syndrome

Fatal Multiple Mitochondrial Dysfunctions Syndrome	Fatal Multiple Mitochondrial Dysfunction Syndrome
Mmds	Multiple Mitochondrial Dysfunction Syndrome
Mitochondrial Dysfunctions, Multiple, Syndrome	Multiple Mitochondrial Dysfunctions Syndrome 1

Multiple Mitochondrial Dysfunctions Syndrome 3

MMDS3	Iba57 Deficiency
Multiple Mitochondrial Dysfunctions Syndrome Type 3	Mitochondrial Dysfunctions, Multiple, Syndrome, Type 3

Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia

Multiple Mitochondrial Dysfunctions Syndrome 2	MMDS2
Bola3 Deficiency	Multiple Mitochondrial Dysfunctions Syndrome Type 2
Mitochondrial Dysfunctions Syndrome, Multiple, Type 2

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Glycine Encephalopathy

Non-Ketotic Hyperglycinemia	Nonketotic Hyperglycinemia
NKH	GCE
Hyperglycinemia, Nonketotic	Hyperglycinemia Nonketotic
Infantile Glycine Encephalopathy	Encephalopathy, Glycine
Glycine Synthase Deficiency	Nka
Neonatal Glycine Encephalopathy	Classic Glycine Encephalopathy
Neonatal Nkh	Neonatal Non-Ketotic Hyperglycinemia
Infantile Nkh	Infantile Non-Ketotic Hyperglycinemia
Non-Ketotic Hyperglycinaemia	Glycine Cleavage Deficiency
Nonketotic Hyperglycinaemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04855	FDX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	FDX2	RGD	RGD:1561264
Bos taurus	FDX2	VGNC	VGNC:55209
Mus musculus	FDX2	MGD	MGI:1915415
Felis catus	FDX2	VGNC	VGNC:102583

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FDX2 - ferredoxin 2 Gene

关于 FDX2

功能概要

FDX2 基因产物(1)

FDX2 蛋白结构

FDX2 蛋白互作信息

关联疾病

直系同源

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FDX2 - ferredoxin 2 Gene

关于 FDX2

功能概要

FDX2 基因产物(1)

FDX2 蛋白结构

FDX2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z