1. Gene
  2. VPS26B - VPS26 retromer complex component B Gene

VPS26B - VPS26 retromer complex component B Gene

中文名称:VPS26 逆转录复合物 B 组份

种属: Homo sapiens

同用名: Pep8b

基因 ID: 112936 | 基因类型: protein coding

关于 VPS26B

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:134,224,671-134,247,788 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 21.5), skin (RPKM 15.9) and 25 other tissues.

功能概要

预计参与细胞内蛋白质转运和逆行转运,核内体至高尔基体。预计在细胞对干扰素-γ 的反应上游或细胞反应中起作用。预测位于早期内体和晚期内体。预计是 retromer 复合体的一部分。预计在内体中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in endosome. [provided by Alliance of Genome Resources, Apr 2022]

VPS26B 基因产物(1)

mRNA Protein Name
NM_052875.5 NP_443107.1 vacuolar protein sorting-associated protein 26B
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24980502 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VPS26B 蛋白结构

Vps26

Vps26: Vacuolar protein sorting-associated protein 26 (6 - 281)

  • 0
  • 100
  • 200
  • 300
  • 336 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 26B

vesicle protein sorting 26B

VPS26B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 28514442
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 32296183
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 32296183
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 26496610
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 33961781
种属内
VPS26B Q4G0F5 VPS35 Homo sapiens Q96QK1 32296183
种属内
VPS26B Q4G0F5 NPLOC4 Homo sapiens Q8TAT6 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 56

Mental Retardation, Autosomal Dominant 56

MRD56

Autosomal Dominant Mental Retardation 56

Autosomal Dominant Intellectual Developmental Disorder 56

Autosomal Dominant Intellectual Developmental Disorder-56

Developmental And Epileptic Encephalopathy 48

DEE48

Epileptic Encephalopathy, Early Infantile, 48

Eiee48

Developmental And Epileptic Encephalopathy, 48

Early Infantile Epileptic Encephalopathy 48

Spastic Paraplegia 39, Autosomal Recessive

SPG39

Ntemnd

Hereditary Spastic Paraplegia 39

Nte-Related Motor Neuron Disorder

Autosomal Recessive Spastic Paraplegia Type 39

Spastic Paraplegia Due To Neuropathy Target Esterase Mutation

Spastic Paraplegia Due To Nte Mutation

Spastic Paraplegia 39

Autosomal Recessive Spastic Paraplegia 39

Nte Related Motor Neuron Disorder

Paraplegia, Spastic, Type 39

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus VPS26B MGD MGI:1917656
Bos taurus VPS26B VGNC VGNC:36815
Canis familiaris VPS26B VGNC VGNC:48281
Rattus norvegicus VPS26B RGD RGD:1597170
Macaca mulatta VPS26B VGNC VGNC:101426
Felis catus VPS26B VGNC VGNC:66961