1. Gene
  2. VPS35 - VPS35 retromer complex component Gene

VPS35 - VPS35 retromer complex component Gene

中文名称:VPS35 retromer 复杂组件

种属: Homo sapiens

同用名: MEM3; PARK17

基因 ID: 55737 | 基因类型: protein coding

关于 VPS35

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,656,132-46,689,178 (from NCBI)

This gene has 12 transcripts (splice variants), 215 orthologues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 28.7), urinary bladder (RPKM 22.9) and 25 other tissues.

功能概要

该基因属于一组液泡蛋白分选 (VPS) 基因。编码的蛋白质是一个大型多聚体复合体的组成部分,称为逆转录复合体,参与蛋白质从内体到反式高尔基体网络的逆行转运。构成这种复合物的酵母和人类蛋白质之间的结构相似性表明它们在功能上存在相似性。在酵母和哺乳动物细胞中的表达研究表明,这种蛋白质直接与 VPS35 相互作用,VPS35 是逆转录酶复合体的核心。[RefSeq 提供,2008 年 7 月]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]

VPS35 基因产物(1)

mRNA Protein Name
NM_018206.6 NP_060676.2 vacuolar protein sorting-associated protein 35
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D1 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
27460146 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11102511 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytic recycling IMP
IMP: 通过突变表型推断
20164305 GOA
involved in mitochondrial fragmentation involved in apoptotic process IMP
IMP: 通过突变表型推断
26618722 GOA
involved in mitochondrion to lysosome vesicle-mediated transport IMP
IMP: 通过突变表型推断
26618722 GOA
involved in negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
25533483 GOA
involved in negative regulation of late endosome to lysosome transport IMP
IMP: 通过突变表型推断
23563491 GOA
involved in neurotransmitter receptor transport, endosome to plasma membrane IDA
IDA: 通过直接分析推断
27460146 GOA
involved in positive regulation of dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
27460146 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
26618722 GOA
involved in positive regulation of mitochondrial fission IMP
IMP: 通过突变表型推断
26618722 GOA
involved in positive regulation of protein catabolic process IGI
IGI: 通过遗传相互作用推断
25533483 GOA
involved in positive regulation of protein localization to cell periphery IMP
IMP: 通过突变表型推断
25533483 GOA
involved in protein localization to endosome IMP
IMP: 通过突变表型推断
28892079 GOA
involved in regulation of dendritic spine maintenance IMP
IMP: 通过突变表型推断
26618722 GOA
involved in regulation of mitochondrion organization IGI
IGI: 通过遗传相互作用推断
26618722 GOA
involved in regulation of protein metabolic process IDA
IDA: 通过直接分析推断
26618722 GOA
involved in regulation of protein metabolic process IGI
IGI: 通过遗传相互作用推断
25533483 GOA
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
18193037 GOA
involved in regulation of terminal button organization IMP
IMP: 通过突变表型推断
26618722 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
15078903 GOA
involved in transcytosis IDA
IDA: 通过直接分析推断
15247922 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11102511 GOA
located in early endosome IDA
IDA: 通过直接分析推断
18160348 GOA
located in endosome IDA
IDA: 通过直接分析推断
15078903 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
27385586 GOA
colocalizes with mitochondrion IDA
IDA: 通过直接分析推断
26618722 GOA
located in mitochondrion-derived vesicle IDA
IDA: 通过直接分析推断
26618722 GOA
part of retromer complex IDA
IDA: 通过直接分析推断
11102511 GOA
part of retromer, cargo-selective complex IDA
IDA: 通过直接分析推断
20164305 GOA
located in tubular endosome IDA
IDA: 通过直接分析推断
15078903 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VPS35 蛋白结构

Vps35

Vps35: Vacuolar protein sorting-associated protein 35 (14 - 753)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 35

hVPS35

VPS35 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436
TSA
24747528
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436 24152121
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436 17891154
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436 24980502
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436 17891154
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436
Y2H
16732284
种属内
VPS35 Q96QK1 VPS26A Homo sapiens O75436 11102511
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0-2 32296183
种属内
VPS35 Q96QK1 VPS26B Homo sapiens Q4G0F5 35271311
种属内
VPS35 Q96QK1 VPS26B Homo sapiens Q4G0F5 24980502
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0
TSA
24747528
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 24980502
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 25416956
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 25416956
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 35271311
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 24152121
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0 17891154
种属内
VPS35 Q96QK1 VPS29 Homo sapiens Q9UBQ0
GMS
11102511
种属内
VPS35 Q96QK1 TBC1D5 Homo sapiens Q92609 24980502
种属内
VPS35 Q96QK1 TBC1D5 Homo sapiens Q92609 33961781
种属内
VPS35 Q96QK1 TBC1D5 Homo sapiens Q92609 35271311
种属内
VPS35 Q96QK1 TBC1D5 Homo sapiens Q92609 37172566
种属间
VPS35 Q96QK1 Vps29 Mus musculus Q9QZ88
ITC
24152121
种属内
VPS35 Q96QK1 WASHC2C Homo sapiens Q9Y4E1 24980502
种属内
VPS35 Q96QK1 WASHC2C Homo sapiens Q9Y4E1 35271311
种属间: 跨种属相互作用 种属内: 同种属相互作用

VPS35 抗体

目录号 产品名 应用 反应物种
HY-P83569 VPS35 Antibody (YA3314) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Parkinson Disease 17

PARK17

Parkinson'S Disease 17

Autosomal Dominant Parkinson Disease 17

Parkinson Disease, Type 17

Hereditary Late-Onset Parkinson Disease

Autosomal Dominant Late-Onset Parkinson Disease

Lopd

Hereditary Late Onset Parkinson Disease

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Glioma
Parkinson Disease 21

PARK21

Parkinson'S Disease 21

Parkinson Disease, Type 21

Kufor-Rakeb Syndrome

Park9

Krppd

KRS

Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia

Autosomal Recessive Parkinson Disease 9

Parkinson Disease 9

Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset

Autosomal Recessive Juvenile Onset Parkinson Disease 9

Parkinson Disease Type 9

Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia

Park 9

Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis

Cln12 Disease

Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis

Parkinson Disease Autosomal Recessive 9

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome

Pallidopyramidal Syndrome

Parkinson Disease 15, Autosomal Recessive

PARK15

Pkps

Pallido-Pyramidal Syndrome

Parkinson'S Disease 15

Autosomal Recessive Early-Onset Parkinson Disease 15

Autosomal Recessive Early-Onset Parkinson'S Disease 15

Pallido-Pyramidal Disease

Parkinson Disease 15

Parkinson Disease 15 Autosomal Recessive

Pps

Parkinson Disease, Type 15

Neuroaxonal Dystrophy

Neuroaxonal Dystrophies

Movement Disease

Movement Disorders

Movement Disorder

Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Gaucher'S Disease

Gaucher Disease

Kerasin Thesaurismosis

Glucocerebrosidase Deficiency

Glucosylceramidase Deficiency

Cerebroside Lipidosis Syndrome

Acid Beta-Glucosidase Deficiency

Glucosylceramide Beta-Glucosidase Deficiency

Acute Cerebral Gaucher Disease

Gaucher Splenomegaly

Glucocerebrosidosis

Glucosyl Cerebroside Lipidosis

Kerasin Lipoidosis

Lipoid Histiocytosis

Glocucerebrosidase Deficiency

Sphingolipidosis 1

Gaucher Syndrome

Gauchers Disease

Gd

Glucosylceramide Lipidosis

Kerasin Histiocytosis

Gaucher Disease, Type 1

Gaucher Disease, Type 2

Gaucher Disease, Type I

Glucocerebrosidase Deficiency

Acid Beta-Glucosidase Deficiency

Gba Deficiency

GD1

Gd I

Gaucher Disease, Noncerebral Juvenile

Gaucher Disease Type 1

Gaucher Disease Type I

Gaucher'S Disease Type I

Gaucher Disease

Gd 1

Non-Cerebral Juvenile Gaucher Disease

GD

Gaucher Disease 1

Adult Non-Neuronopathic Gaucher Disease

Noncerebral Juvenile Gaucher Disease

Type 1 Gaucher Disease

Gaucher Disease, Type 1

Sphingolipidosis

Sphingolipidoses

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy

Steele-Richardson-Olszewski Syndrome

Supranuclear Palsy, Progressive

Progressive Supranuclear Ophthalmoplegia

Psp

PSNP1

Familial Progressive Supranuclear Palsy

Richardson'S Syndrome

Psp Syndrome

Progressive Supranuclear Palsy 1

Supranuclear Palsy Progressive

Ophthalmoplegia, Supranuclear, Progressive

Steele-Richardson-Olszewksi Syndrome

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus VPS35 VGNC VGNC:36818
Felis catus VPS35 VGNC VGNC:66964
Canis familiaris VPS35 VGNC VGNC:48285
Rattus norvegicus VPS35 RGD RGD:1589784
Macaca mulatta VPS35 VGNC VGNC:78928
Mus musculus VPS35 MGD MGI:1890467