1. Gene
  2. VPS29 - VPS29 retromer complex component Gene

VPS29 - VPS29 retromer complex component Gene

中文名称:VPS29 retromer 复杂组件

种属: Homo sapiens

同用名: DC7; DC15; PEP11

基因 ID: 51699 | 基因类型: protein coding

关于 VPS29

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:110,491,083-110,502,111 (from NCBI)

This gene has 12 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in fat (RPKM 31.1), esophagus (RPKM 28.7) and 25 other tissues.

功能概要

该基因属于一组液泡蛋白分选 (VPS) 基因,当功能受损时,会破坏液泡水解酶的有效传递。由该基因编码的蛋白质是一个大型多聚体复合体的组成部分,称为逆转录复合体,参与蛋白质从核内体到反式高尔基体网络的逆行转运。这种 VPS 蛋白可能参与逆行囊泡离开前液泡室的逆转录体外壳内壳的形成。已为该基因发现了编码不同亚型和代表非蛋白质编码转录物的可变剪接变体。[RefSeq 提供,2013 年 8 月]

This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]

VPS29 基因产物(4)

mRNA Protein Name
NM_001282150.2 NP_001269079.1 vacuolar protein sorting-associated protein 29 isoform 3
NM_001282151.2 NP_001269080.1 vacuolar protein sorting-associated protein 29 isoform 4
NM_016226.5 NP_057310.1 vacuolar protein sorting-associated protein 29 isoform 1
NM_057180.3 NP_476528.1 vacuolar protein sorting-associated protein 29 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11102511 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytic recycling IMP
IMP: 通过突变表型推断
28892079 GOA
NOT involved in regulation of autophagy IMP
IMP: 通过突变表型推断
24603492 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
11102511 GOA
part of retromer complex IDA
IDA: 通过直接分析推断
11102511 GOA
part of retromer, cargo-selective complex IDA
IDA: 通过直接分析推断
27385586 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VPS29 蛋白结构

Metallophos_2

Metallophos_2: Calcineurin-like phosphoesterase superfamily domain (1 - 156)

  • 0
  • 100
  • 182 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 29

PEP11 homolog

VPS29 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VPS29 Q9UBQ0 TBC1D5 Homo sapiens B9A6K1 25416956
种属内
VPS29 Q9UBQ0 VPS26A Homo sapiens O75436 17891154
种属内
VPS29 Q9UBQ0 VPS26A Homo sapiens O75436 35271311
种属内
VPS29 Q9UBQ0 VPS26A Homo sapiens O75436
GMS
11102511
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 35271311
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 25502805
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 37172566
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1
ITC
24980502
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1
GMS
17891154
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 25416956
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 17891154
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 33961781
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 11102511
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 17891154
种属内
VPS29 Q9UBQ0 VPS35 Homo sapiens Q96QK1 31515488
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2 35271311
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2 37172566
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2
ITC
37172566
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2 37172566
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2 33961781
种属内
VPS29 Q9UBQ0 VPS35L Homo sapiens Q7Z3J2 37172566
种属内
VPS29 Q9UBQ0 TBC1D5 Homo sapiens Q92609 35271311
种属内
VPS29 Q9UBQ0 TBC1D5 Homo sapiens Q92609 37172566
种属内
VPS29 Q9UBQ0 TBC1D5 Homo sapiens Q92609 24603492
种属内
VPS29 Q9UBQ0 TBC1D5 Homo sapiens Q92609 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ritscher-Schinzel Syndrome

3c Syndrome

Ccc Dysplasia

Craniocerebellocardiac Dysplasia

Cranio-Cerebello-Cardiac Dysplasia

Spastic Paraplegia 36, Autosomal Dominant

SPG36

Hereditary Spastic Paraplegia 36

Autosomal Dominant Spastic Paraplegia Type 36

Autosomal Dominant Spastic Paraplegia 36

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus VPS29 VGNC VGNC:82553
Bos taurus VPS29 VGNC VGNC:36816
Canis familiaris VPS29 VGNC VGNC:48283
Rattus norvegicus VPS29 RGD RGD:1308332
Macaca mulatta VPS29 VGNC VGNC:78956
Mus musculus VPS29 MGD MGI:1928344
Others VPS29 NCBI