1. Gene
  2. VPS26A - VPS26 retromer complex component A Gene

VPS26A - VPS26 retromer complex component A Gene

中文名称:VPS26 逆转录复合物组分 A

种属: Homo sapiens

同用名: HB58; PEP8A; VPS26; Hbeta58

基因 ID: 9559 | 基因类型: protein coding

关于 VPS26A

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,124,178-69,174,412 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 20.4), esophagus (RPKM 15.7) and 25 other tissues.

功能概要

该基因属于一组液泡蛋白分选 (VPS) 基因。编码的蛋白质是一个大型多聚体复合体的组成部分,称为逆转录复合体,参与蛋白质从内体到反式高尔基体网络的逆行转运。构成这种复合物的酵母和人类蛋白质之间的结构相似性表明它们在功能上存在相似性。在酵母和哺乳动物细胞中的表达研究表明,这种蛋白质直接与 VPS35 相互作用,VPS35 是逆转录酶复合体的核心。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 7 月]

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

VPS26A 基因产物(5)

mRNA Protein Name
NM_001035260.3 NP_001030337.1 vacuolar protein sorting-associated protein 26A isoform 2
NM_001318944.2 NP_001305873.1 vacuolar protein sorting-associated protein 26A isoform 3
NM_001318945.2 NP_001305874.1 vacuolar protein sorting-associated protein 26A isoform 4
NM_001318946.2 NP_001305875.1 vacuolar protein sorting-associated protein 26A isoform 5
NM_004896.5 NP_004887.2 vacuolar protein sorting-associated protein 26A isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11102511 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endocytic recycling IMP
IMP: 通过突变表型推断
21602791 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: 通过突变表型推断
15078903 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
15078903 GOA
located in endosome IDA
IDA: 通过直接分析推断
20682791 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
22431521 GOA
part of retromer complex IDA
IDA: 通过直接分析推断
11102511 GOA
part of retromer, cargo-selective complex IDA
IDA: 通过直接分析推断
27385586 GOA
located in tubular endosome IDA
IDA: 通过直接分析推断
15078903 GOA
located in vesicle IDA
IDA: 通过直接分析推断
20682791 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VPS26A 蛋白结构

Vps26

Vps26: Vacuolar protein sorting-associated protein 26 (8 - 283)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
蛋白主名 其他名称

vacuolar protein sorting-associated protein 26A

VPS26 retromer complex comonent A

VPS26A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VPS26A O75436 MORF4L1 Homo sapiens Q9UBU8-2 32296183
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 28514442
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 15078903
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1
GMS
17891154
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 11102511
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1
GMS
11102511
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 26496610
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 16732284
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 32296183
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 33961781
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 37172566
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1 11102511
种属内
VPS26A O75436 VPS35 Homo sapiens Q96QK1
TEM
17891154
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0 26496610
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0 16732284
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0 11102511
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0 33961781
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0
GMS
11102511
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0
TEM
17891154
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0 37172566
种属内
VPS26A O75436 VPS29 Homo sapiens Q9UBQ0
GMS
17891154
种属间: 跨种属相互作用 种属内: 同种属相互作用

VPS26A 抗体

目录号 产品名 应用 反应物种
HY-P81801 VPS26 Antibody (YA1546) WB, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Ritscher-Schinzel Syndrome

3c Syndrome

Ccc Dysplasia

Craniocerebellocardiac Dysplasia

Cranio-Cerebello-Cardiac Dysplasia

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus VPS26A MGD MGI:1353654
Canis familiaris VPS26A VGNC VGNC:48280
Felis catus VPS26A VGNC VGNC:66960
Rattus norvegicus VPS26A RGD RGD:1359254
Macaca mulatta VPS26A VGNC VGNC:78775
Bos taurus VPS26A VGNC VGNC:36814