2. Gene
  3. LARP4 - La ribonucleoprotein 4 Gene

LARP4 - La ribonucleoprotein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖核蛋白 4

种属: Homo sapiens

同用名: PP13296

基因 ID: 113251 | 基因类型: protein coding

关于 LARP4

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,400,885-50,480,004 (from NCBI)

This gene has 18 transcripts (splice variants), 317 orthologues and 6 paralogues. Ubiquitous expression in liver (RPKM 13.3), adrenal (RPKM 12.0) and 25 other tissues.

功能概要

启用 mRNA 3'-UTR 结合活性和 poly (A) 结合活性。参与细胞骨架组织；翻译的积极调节；和细胞形态发生的调节。位于胞质溶胶中。与细胞质应激颗粒共定位；胞质小核糖体亚单位；和多核糖体。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA 3'-UTR binding activity and poly(A) binding activity. Involved in Cytoskeleton organization; positive regulation of translation; and regulation of cell morphogenesis. Located in cytosol. Colocalizes with cytoplasmic stress granule; cytosolic small ribosomal subunit; and polysome. [provided by Alliance of Genome Resources, Apr 2022]

LARP4 基因产物(30)

mRNA Protein Name
NM_001170803.2 NP_001164274.1 la-related protein 4 isoform d
NM_001170804.2 NP_001164275.1 la-related protein 4 isoform e
NM_001170808.2 NP_001164279.1 la-related protein 4 isoform f
NM_001330415.2 NP_001317344.1 la-related protein 4 isoform g
NM_001352304.2 NP_001339233.1 la-related protein 4 isoform h
NM_001352305.2 NP_001339234.1 la-related protein 4 isoform i
NM_001352306.2 NP_001339235.1 la-related protein 4 isoform j
NM_001352307.2 NP_001339236.1 la-related protein 4 isoform k
NM_001352308.2 NP_001339237.1 la-related protein 4 isoform l
NM_001352309.2 NP_001339238.1 la-related protein 4 isoform m
NM_001352310.2 NP_001339239.1 la-related protein 4 isoform m
NM_001352311.2 NP_001339240.1 la-related protein 4 isoform m
NM_001352312.2 NP_001339241.1 la-related protein 4 isoform m
NM_001352313.2 NP_001339242.1 la-related protein 4 isoform m
NM_001352314.2 NP_001339243.1 la-related protein 4 isoform m
NM_001352315.2 NP_001339244.1 la-related protein 4 isoform n
NM_001352316.2 NP_001339245.1 la-related protein 4 isoform o
NM_001352317.2 NP_001339246.1 la-related protein 4 isoform o
NM_001352318.2 NP_001339247.1 la-related protein 4 isoform p
NM_001352319.2 NP_001339248.1 la-related protein 4 isoform q
NM_001352320.2 NP_001339249.1 la-related protein 4 isoform r
NM_001352321.2 NP_001339250.1 la-related protein 4 isoform s
NM_001352322.2 NP_001339251.1 la-related protein 4 isoform t
NM_001352323.2 NP_001339252.1 la-related protein 4 isoform u
NM_001352324.2 NP_001339253.1 la-related protein 4 isoform h
NM_001352325.2 NP_001339254.1 la-related protein 4 isoform v
NM_001352326.2 NP_001339255.1 la-related protein 4 isoform w
NM_052879.5 NP_443111.4 la-related protein 4 isoform a
NM_199188.3 NP_954658.2 la-related protein 4 isoform b
NM_199190.3 NP_954660.1 la-related protein 4 isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
26001795 GOA
enables poly(A) binding IDA
IDA: 通过直接分析推断
21098120 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21098120 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoskeleton organization IMP
IMP: 通过突变表型推断
21834987 GOA
involved in positive regulation of translation IMP
IMP: 通过突变表型推断
21098120 GOA
involved in post-transcriptional regulation of gene expression IDA
IDA: 通过直接分析推断
26001795 GOA
involved in regulation of cell morphogenesis IMP
IMP: 通过突变表型推断
21834987 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cytoplasmic stress granule IDA
IDA: 通过直接分析推断
21098120 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21098120 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
21098120 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LARP4 蛋白结构

La

La: La domain (123 - 180)

  • 0
  • 200
  • 400
  • 600
  • 724 a.a.
蛋白主名 其他名称

la-related protein 4

La ribonucleoprotein domain family member 4

LARP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LARP4 Q71RC2 LRRK2 Homo sapiens Q5S007
Protein Array
29513927
种属内
LARP4 Q71RC2 NPM1 Homo sapiens P06748
Crosslink
30021884
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma

Embryonal Carcinoma Of Testis

Embryonal Carcinoma Of The Testis
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07528 LARP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07529 LARP4B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LARP4 VGNC VGNC:42589
Felis catus LARP4 VGNC VGNC:63193
Rattus norvegicus LARP4 RGD RGD:6499275
Bos taurus LARP4 VGNC VGNC:55059
Mus musculus LARP4 MGD MGI:2443114
Macaca mulatta LARP4 VGNC VGNC:74111
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