2. Gene
  3. VSIG4 - V-set and immunoglobulin domain containing 4 Gene

VSIG4 - V-set and immunoglobulin domain containing 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 V 组和免疫球蛋白结构域 4

种属: Homo sapiens

同用名: CRIg; Z39IG

基因 ID: 11326 | 基因类型: protein coding

关于 VSIG4

Cytogenetic location: Xq12 Genomic coordinates (GRCh38): X:66,021,738-66,040,080 (from NCBI)

This gene has 5 transcripts (splice variants) and 121 orthologues. Broad expression in placenta (RPKM 50.4), lung (RPKM 39.9) and 19 other tissues.

功能概要

该基因编码一个 v 集和免疫球蛋白结构域的蛋白质，该蛋白质在结构上与免疫调节蛋白 B7 家族相关。编码的蛋白质可能是 T 细胞反应的负调节因子。该蛋白质也是补体成分 3 片段 C3b 和 iC3b 的受体。交替剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the Complement Component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VSIG4 基因产物(5)

mRNA Protein Name
NM_001100431.2 NP_001093901.1 V-set and immunoglobulin domain-containing protein 4 isoform 2 precursor
NM_001184830.2 NP_001171759.1 V-set and immunoglobulin domain-containing protein 4 isoform 4 precursor
NM_001184831.2 NP_001171760.1 V-set and immunoglobulin domain-containing protein 4 isoform 3 precursor
NM_001257403.2 NP_001244332.1 V-set and immunoglobulin domain-containing protein 4 isoform 5 precursor
NM_007268.3 NP_009199.1 V-set and immunoglobulin domain-containing protein 4 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables complement component C3b binding IPI
IPI: 通过物理相互作用推断
17051150 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16530040 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of complement activation, alternative pathway IPI
IPI: 通过物理相互作用推断
17051150 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IPI
IPI: 通过物理相互作用推断
17051150 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VSIG4 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (26 - 135)

Ig_3

Ig_3: Immunoglobulin domain (142 - 213)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

V-set and immunoglobulin domain-containing protein 4

Ig superfamily protein

VSIG4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VSIG4 Q9Y279 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
种属内
VSIG4 Q9Y279 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 VSIG4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71423 VSIG4 Protein, Human (HEK293, Fc) Q9Y279-1 (R20-V284) ≥95%
HY-P71424 VSIG4 Protein, Human (264a.a, HEK293, His) Q9Y279-1 (R20-P283) ≥95%

关联疾病

疾病名称 别名
Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

Atypical Hemolytic Uremic Syndrome

Hemolytic Uremic Syndrome, Atypical, Susceptibility To

Ahus

AHUS1

Hemolytic-Uremic Syndrome

Ahus 1

Ahus, Susceptibility To, 1

Hemolytic Uremic Syndrome, Atypical

Non-Shiga-Like Toxin-Associated Hus

Non-Stx-Hus

Nonenteropathic Hus

Atypical Hus

Shiga Toxin-Associated Hemolytic Uremic Syndrome

D+ Hus

Ehec-Hus

Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

Hemolytic Uremic Syndrome With Diarrhea

Stec-Hus

Shiga-Like Toxin-Associated Hus

Stx-Hus

Typical Hus

Typical Hemolytic Uremic Syndrome

Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

Atypical Hus With Anti-Factor H Antibodies

Ahus With Anti-Factor H Antibodies

Ahus With Neutralizing Autoantibodies Against Factor H

Hemolytic Uremic Syndrome Atypical 1

Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

D Hus

Hemolytic-Uremic Syndrome Without Diarrhea

Hemolytic-Uremic Syndrome, Atypical, Type 1

Hemolytic Uremic Syndrome, Typical
Chromophobe Renal Cell Carcinoma

Chromophobe Adenocarcinoma

Chromophobe Carcinoma Of Kidney

Kidney Chromophobe

Renal Cell Carcinoma, Chromophobe Cell

Crcc

Chrcc

Chromophobe Renal Cell Adenocarcinoma

Chromophobe Renal Carcinoma

Chromophobe Carcinoma
Diamond-Blackfan Anemia 1

Aase Syndrome

DBA1

Erythrogenesis Imperfecta

Aase-Smith Syndrome Ii

Dba

Blackfan-Diamond Syndrome

Bds

Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

Anemia, Congenital Erythroid Hypoplastic

Red Cell Aplasia, Pure, Hereditary

Aregenerative Anemia, Chronic Congenital

Rps19-Related Diamond-Blackfan Anemia

Chronic Congenital Aregenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Pure Hereditary Red Cell Aplasia

Anemia, Diamond-Blackfan, Type 1

Anemia, Diamond-Blackfan

Aase Smith Syndrome 2

Familial Hypoplastic Anaemia With Malformations

Constitutional Pure Red Cell Aplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15709 VSIG4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus VSIG4 RGD RGD:1564659
Macaca mulatta VSIG4 VGNC VGNC:79062
Mus musculus VSIG4 MGD MGI:2679720
Bos taurus VSIG4 VGNC VGNC:36840
Canis familiaris VSIG4 VGNC VGNC:48308
Felis catus VSIG4 VGNC VGNC:66978
Macaca fascicularis VSIG4 NCBI NCBI:102144784
Others VSIG4 NCBI
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