1. Gene
  2. SCRG1 - stimulator of chondrogenesis 1 Gene

SCRG1 - stimulator of chondrogenesis 1 Gene

中文名称:软骨形成刺激物 1

种属: Homo sapiens

同用名: SCRG-1

基因 ID: 11341 | 基因类型: protein coding

关于 SCRG1

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:173,384,701-173,519,144 (from NCBI)

This gene has 2 transcripts (splice variants) and 142 orthologues. Biased expression in brain (RPKM 46.0), testis (RPKM 30.3) and 3 other tissues.

功能概要

痒病反应基因 1 与在传染性海绵状脑病中观察到的神经退行性变化有关。它可能在宿主对朊病毒相关感染的反应中发挥作用。由于其疏水性 N 末端,痒病反应蛋白 1 可能部分包含在膜中或由细胞分泌。此外,编码的蛋白质可以与骨髓基质细胞抗原 1 (BST1) 相互作用,以增强人间充质干细胞在组织和骨再生过程中的分化潜能。[RefSeq 提供,2016 年 7 月]

Scrapie-responsive gene 1 is associated with neurodegenerative changes observed in transmissible spongiform encephalopathies. It may play a role in host response to prion-associated infections. The scrapie responsive protein 1 may be partly included in the membrane or secreted by the cells due to its hydrophobic N-terminus. In addition, the encoded protein can interact with bone marrow stromal cell antigen 1 (BST1) to enhance the differentiation potentials of human mesenchymal stem cells during tissue and bone regeneration. [provided by RefSeq, Jul 2016]

SCRG1 基因产物(2)

mRNA Protein Name
NM_001329597.2 NP_001316526.1 scrapie-responsive protein 1 precursor
NM_007281.4 NP_009212.1 scrapie-responsive protein 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SCRG1 蛋白结构

SCRG1

SCRG1: Scrapie-responsive protein 1 (21 - 98)

  • 0
  • 98 a.a.
蛋白主名 其他名称

scrapie-responsive protein 1

scrapie responsive gene 1

SCRG1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SCRG1 O75711 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra SCRG1 O75711 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra SCRG1 O75711 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra SCRG1 O75711 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra SCRG1 O75711 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra SCRG1 O75711 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra SCRG1 O75711 CATSPER1 Homo sapiens Q8NEC5
Y2H Array
25416956
Intra SCRG1 O75711 CATSPER1 Homo sapiens Q8NEC5
Y2H Prey Pooling
25416956
Intra SCRG1 O75711 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra SCRG1 O75711 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra SCRG1 O75711 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scrapie
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SCRG1 VGNC VGNC:50423
Mus musculus SCRG1 MGD MGI:1328308
Felis catus SCRG1 VGNC VGNC:64934
Bos taurus SCRG1 VGNC VGNC:34364
Rattus norvegicus SCRG1 RGD RGD:68377